5′-Hydroxyzearalenol,a new β-resorcylic macrolide from Fusarium sp. 05ABR26  

作　　者：Ling Ling Zhao Yue Gai Hisayoshi Kobayashi Chang Qi Hu Hui Ping Zhang 

机构地区：[1]Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China [2]Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan

出　　处：《Chinese Chemical Letters》2008年第9期1089-1092,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation(No.30371680)of the People's Republic of China.

摘　　要：A new β-resorcylic macrolide, 5＇-hydroxyzearalenol （1）, was isolated from the culture broth of a marine-derived fungus Fusarium sp. 05ABR26. Three known compounds, zearalenone （2）, 8＇-hydroxyzearalenone （3） and zearalenol （4） were also isolated. The structure and relative stereochemistry of 1 were elucidated on the basis of spectroscopic data and single-crystal X-ray diffraction data. Compound 2 displayed potent inhibitory activity against Pyricularia oryzae with a MIC value of 6.25 μg/mL, while compound 3 was much less active; however, 1 and 4 showed no obvious activity.A new β-resorcylic macrolide, 5＇-hydroxyzearalenol （1）, was isolated from the culture broth of a marine-derived fungus Fusarium sp. 05ABR26. Three known compounds, zearalenone （2）, 8＇-hydroxyzearalenone （3） and zearalenol （4） were also isolated. The structure and relative stereochemistry of 1 were elucidated on the basis of spectroscopic data and single-crystal X-ray diffraction data. Compound 2 displayed potent inhibitory activity against Pyricularia oryzae with a MIC value of 6.25 μg/mL, while compound 3 was much less active; however, 1 and 4 showed no obvious activity.

关 键 词：5＇-Hydroxyzearalenol Fusarium sp. X-ray diffraction data Pyricularia oryzae 

分 类 号：TQ655[化学工程—精细化工] O622.4[理学—有机化学]