新型官能团化聚己内酯的研究进展  

Research Progress on the Functionalized Poly(ε-caprolactone)

作　　者：戴炜枫[1] 茹敏良[1] 何月英[1] 郎美东[1] 

机构地区：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237

出　　处：《高分子通报》2008年第9期10-19,共10页Polymer Bulletin

基　　金：国家自然科学基金(20374013;20674019);新世纪优秀人才(NCET-04-0413);上海市曙光计划;上海市科委项目(03JC14023;05DJ14005);博士点基金(20060251015)的资助

摘　　要：聚己内酯(PCL)是一种具有良好药物透过性的可生物降解的脂肪族聚酯,是一类优良的药物载体。由于其结晶性强,亲水性差,生物降解速度慢,限制了其在组织工程等生物医用领域更广泛的临床应用。在PCL主链上引入功能性官能团既可有效地降低其结晶性、改善其亲水性、调控其降解速率,同时又可通过反应性官能团进行进一步的化学改性或生物活性化修饰,已成为生物可降解材料新的研究热点。本文综述了含侧基官能团己内酯单体的合成及其聚合反应,简要介绍了侧基官能团对聚己内酯性能的影响。Poly（ε-caprolactone） （PCL） is a kind of aliphatic polyesters which is biodegradable, biocompatible and drug-permeable. However, the high crystallinity, low hydrophilicity and degradation rate limit its further applications in biomedical areas. Attachment of functional groups along the chain is highly desirable to tailor the macroscopic properties of these aliphatic polyesters, e.g. crystallinity, hydrophilicity, biodegradation rate, bioadhesion and mechanical properties. Moreover, pendent functional groups can be used to covalently attach molecules or probes of biological interest. In this article, the synthesis and ring-opening polymerization （ROP） of substituted ε-caprolactones were reviewed. Also the effect of functional groups to PCL was introduced briefly.

关 键 词：聚己内酯 侧基官能团 化学改性 生物活性化修饰 生物可降解材料 开环聚合 

分 类 号：O633.14[理学—高分子化学] TQ325.14[理学—化学]