2,3-二取代-5-氟脲嘧啶的合成及其抗肿瘤活性研究(英文)  

Study on the Synthesis of 2,3 Disubstituted 5 fluorouracils and Their Antitumor Activities

作　　者：孙昌俊[1] 李洪祥[1] 戚聿新[1] 王义贵[1] 张纪明[1] 焦向华 

机构地区：[1]山东大学化学系

出　　处：《合成化学》1997年第3期221-224,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以相转移催化法或在无水体系中合成了十个未见文献报道的２，３－二取代－５－氟脲嘧啶化合物，它们的结构经ＩＲ、１ＨＮＭＲ，元素分析或ＭＳ等确证。其中有些化合物具有一定的抗肿瘤活性。Ten new 2,3 disubstituted 5 fluorouracil derivatives were prepared via phase transfer catalysis or in anhydrous system. Their structures were confirmed by IR, 1H NMR, elementary analysis or MS. The preliminary antitumor tests showed that some of the compounds exhibited certain activities.

关 键 词：氟脲嘧啶 抗癌化合物 相转移催化 抗癌药 

分 类 号：O626.41[理学—有机化学] R979.1[理学—化学]