复发性流产与β-纤维蛋白原基因-455 G/A多态性关系的研究  

Study on association of β-fibrinogen gene G/A-455 polymorphisms with recurrent spontaneous abortion

作　　者：蔡秀娟[1] 郑梅玲[1] 

机构地区：[1]山西医科大学第一医院妇产科遗传研究室,太原030001

出　　处：《中国优生与遗传杂志》2008年第9期15-16,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血浆纤维蛋白原(Fg)及βFg-455G/A基因多态性与山西地区汉族妇女复发性流产的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测复发性流产组30例和对照组30例βFg-455G/A基因的多态性,并测定其血浆纤维蛋白原(Fg)的含量。结果经χ2检验,各基因型构成比和等位基因频率在两组间均无显著性差异(P>0.05);复发性流产组血浆Fg水平(2.31±0.57g/L)较对照组(3.08±0.57g/L)显著降低(P<0.05)。结论本研究发现血浆纤维蛋白原水平降低是复发性流产的危险因素,βFg-455G/A基因多态性不会影响复发性流产血浆纤维蛋白原水平。Objective： To investigate the relationship between β - Fibrinogen gene G/A -455 polymorphisms and recurrent spon- taneous abortion of Han nationality in Shanxi province. Methods ： β - Fibrinogen gene G/A -455 polymorphisms have been detected using PCR - RFLP technique in 30 patients with recurrent spontaneous abortion （RSA） and in 30 healthy controls （ CON）. The lev- els of plasma fibrinogen were determined as well. Results - No significant difference was found in genotypes and the allele frequencies between the CON group and RSA group （x^2 test, P 〉0. 05 ） . The plasma fibrinogen level in RSA group was significantly lower than in CON groups （2. 31 ±0. 57 g/L vs 3. 08 ±0. 57 g/L, P 〈0.05 ） . Conclusion： The low level of Fibrinogen is a probably risk factor of recurrent spontaneous abortion. β - Fibrinogen gene G/A - 455 polymorphisms would not affect plasma fibrinogen levels of recurrent abortion.

关 键 词：β-纤雏蛋白原 聚合酶链反应-限制性片段长度多态性 复发性流产 

分 类 号：R714.21[医药卫生—妇产科学]