碳纳米颗粒的放射性^99mTc标记  

^(99m)Tc Labeling of Carbon Nanomaterials

作　　者：诸颖[1] 李玉峰[1] 张小勇[1] 李晴暖[1] 李文新[1] 

机构地区：[1]中国科学院上海应用物理研究所纳米生物医药研究室

出　　处：《原子核物理评论》2008年第3期305-310,共6页Nuclear Physics Review

基　　金：国家自然科学基金资助项目(10475109,10775168);国家重点基础研究发展规划资助项目(2006CB705605);上海市科委纳米专项基金资助项目(0552nm033,0652nm016,0752nm021)~~

摘　　要：探索了影响氯化亚锡还原法制备碳纳米管和不同粒径纳米碳黑的99mTc标记化合物的多种因素,在给定实验条件下,99mTc的标记率能够稳定达到90%以上。细胞培养液中标记物的放射化学纯度在2.5h中保持在(86±4)%范围内。制备的标记化合物满足碳纳米颗粒细胞摄取率测定和细胞毒性机制研究的实验要求。实验结果提示,99mTc标记过程是基于还原得到的低价Tc在碳纳米颗粒表面上的物理吸附机理。The effects of experimental conditions on preparation of ^99mTc-labeled carbon nanotubes and nanocarbon blacks by SnCl2 were investigated. At given conditions the labeling yields were over 90%. In a culture medium, the radiochemical purity of the labeling compounds kept （86±4）% within 2.5 h. The ^99mTc labeled multi-walled carbon nanotubes （MWNTs） and nanocarbon blackes （NCBs） obtained in this work met satisfactory experimental demands for study of cellular uptake and toxicity. The experiments showed that the labeling process was based on physical adsorption of low valent technetium resulted from reduction reaction on the surface of the carbon nanomaterials.

关 键 词：^99MTC标记 多壁碳纳米管 纳米碳黑 

分 类 号：R817.1[医药卫生—影像医学与核医学]