防风多糖和IL-2体外对小鼠NK、LAK细胞活性的影响及体内抗移植瘤生长的实验研究  

IN Vitro Effects of Fangfeng Polysaccharide and IL-2 on Mouse NK and LAK Cell Activity and Their in Vivo Effects of Inhibiting the Growth of S_（180) Implanted Tumor

作　　者：李莉[1] 周勇[1] 张丽[1] 陆蕴如[1] 严宣佐[1] 葛东宇[1] 邓巧虹[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《北京中医药大学学报》1997年第5期39-40,共2页Journal of Beijing University of Traditional Chinese Medicine

基　　金：卫生部科学研究基金

摘　　要：观察了防风多糖、IL－2体外对NK及LAK细胞杀瘤活性的影响及体内对S180移植瘤生长的抑制作用。结果显示：防风多糖在一定浓度范围内能提高NK、LAK的杀瘤活性，且防风多糖与IL－2联合应用时效果更佳；防风多糖与IL－2体内应用均能抑制S180移植瘤的生长，且防风多糖与IL－2联合应用时，抑瘤率显著提高。In vitro effects of Fangfeng polysaccharide (FP) and IL-2 on cytotoxicity of NK and LAK cells and their in vivo effects of inhibiting the growth of S180 so implanted tumor were studied. The results showed that FP could enhance cytotoxiclty of NK and LAK cells in vitro and the combination of FP and IL-2 produced a stronger effect. The results also showed that both FP and IL-2 could inhibit the growth of S180 implanted tumor in vivo, and the tumor-inhibiting rate was significantly increased when FP was used in combination with IL-2.

关 键 词：防风多糖 IL-2 NK LAK 抗肿瘤作用 白细胞介素2 

分 类 号：R979.5[医药卫生—药品] R979.1[医药卫生—药学]