人Hrs　cDNA的克隆与序列分析  

Cloning and Sequence Analysis of Human Hrs cDNA

作　　者：卢令格[1] 驹田雅之 喜多村直实 

机构地区：[1]首都医科大学附属北京友谊医院北京市临床医学研究所 [2]日本关西医科大学肝脏研究所

出　　处：《首都医科大学学报》1997年第3期238-241,共4页Journal of Capital Medical University

摘　　要：以小鼠ＨｒｓｃＤＮＡ为探针从人胎盘ｃＤＮＡ文库中克隆出人ＨｒｓｃＤＮＡ，其全长为２９１０ｂｐ，所编码的蛋白质含７７７个氨基酸。人ＨｒｓｃＤＮＡ与小鼠ＨｒｓｃＤＮＡ间高度保守。推定的氨基酸序列含有锌指样结构域、脯氨酸丰富区及脯氨酸、谷氨酰胺丰富区。The human Hrs cDNA was cloned from human placenta library. It was 2 910 bp in length encoding a protein of 777 amino acids with a calculated molecular weight of 85 550.Comparison of human Hrs cDNA and deduced amino acid sequence with their mouse couterpart, it shared homo logy of 85% in nucleotid sequence and 92.5% in amino acids sequence, respectively. The human Hrs also contained a zinc finger like domain, a proline rich region and a proline and glutamine rice region.

关 键 词：HRS CDNA 分子克隆 核苷酸序列 

分 类 号：Q785[生物学—分子生物学]