喘息型支气管炎患者血清ECP检测的应用  

Study of the Clinical Application of Serum ECP Measurement in Asthmatic Bronchitis

作　　者：徐坚纲[1] 姚迪 黎明[2] 

机构地区：[1]上海第二医科大学附属新华医院呼吸内科,200092 [2]上海第二医科大学附属新华医院检验科

出　　处：《上海第二医科大学学报》1997年第5期366-368,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：测定25例慢性单纯型支气管炎患者血清嗜酸性细胞阳离子蛋白（eosinophilcationicprotein，ECP）和43例喘息型支气管炎因症状加重而住院者其治疗前后血清ECP水平、血白细胞、嗜酸粒细胞计数和通气功能FEV1／FVC％。结果发现喘息型支气管炎急性发作患者治疗前后ECP水平显著高于慢性单纯型支气管炎患者（P＜0．01）。经积极治疗一周后，ECP水平、血白细胞及嗜酸粒细胞计数则大幅下降（P＜0．05）。但FEV1／FVC％改善不明显（P＞0．05）。血清ECP水平主要取决于嗜酸性细胞激活状态和分泌蛋白的能力，用以反映过敏性疾患的活动情况。本实验提示喘息型支气管炎患者急性发作期间除有感染外，可能与支气管哮喘一样，有过敏因素参与。血清ECP检测可用于监测喘息型支气管炎患者高反应性炎症的程度。Serum eosinophil cationic protein (ECP) was measured in 25 patients with simple chronic bronchitis, and ECP, white blood cell count (WBC), eosinophil count (EOS) and FEV1/FVC% were measured in 43 patients with asthmatic bronchitis hospitalized because of severe symptoms of cough, sputum and pant, before and after treatment. The result showed that the level of ECP of patients with asthmatic bronchitis during acute attacks before and after treatment was higher than that of patients with simple chronic bronchitis (P＜0.01). After the use of antibiotics and corticosteroids by mouth, inhalation, or iv drop for one week the levels of ECP, WBC and EOS decreased significantly (P＜0.05). The improvement of FEV1/FVC% was not obvious (P＞0.05). The level of ECP depends mainly upon the activated condition and ability of protein secretion of eosinophil, and it generally reflects the activity of allergic diseases. Our study suggested that asthmatic bronchitis was associated with allergic factors besides infection like asthma during acute attacks. Serum ECP might be a useful marker for monitoring the severity of disease states of patients with asthmatic bronchitis.

关 键 词：喘息型 支气管炎 ECP 嗜酸粒细胞 通气功能 

分 类 号：R562.21[医药卫生—呼吸系统]