sHLA-G在子痫前期患者的表达及意义  

The Significance and Expression of Soluble HLA-G Protein in Preeclampsia Serum

作　　者：侯彩英[1] 闵保华[1] 蔡颖[1] 赵宏喜[1] 侯丽英 姚元庆[1] 

机构地区：[1]第四军医大学唐都医院妇产科,陕西西安710038 [2]辅仁医院妇产科,陕西西安710038

出　　处：《现代生物医学进展》2008年第10期1905-1906,共2页Progress in Modern Biomedicine

摘　　要：目的:检测子痫前期患者sHLA-G水平,探讨母血sHLA-G的水平和妊娠高血压疾病的关系。方法:采用酶联免疫吸附法检测20例正常孕妇晚期和20例子痫前期患者血清sHLA-G水平。结果:在正常妊娠组sHLA-G血清中的水平为10.72±3.40ng/mL;子痫前期组为9.46±5.10ng/mL。子痫前期组sHLA-G水平明显低于正常妊娠晚期组,差异有显著性意义(P<0.05)。结论:sHLA-G可能与子痫前期患者的发病有关系。Objective： To detect the serum volume of soluble HLA-G （sHLA-G） in preeclampsia, and to explore the relation between soluble HLA-G and the preeclampsia. Methods： Serum samples were collected from 40 pregnant women （normal group 20 cases, preeclampsia group 20 cases ）, sHLA-G levels were determined with enzyme-linked immunosorbent assay （ ELISA ）, Results： The average of sHLA-G in preeclampsia group before labor is 9.46：1：5.10 ng/mL, significantly lower than that of the normal group （ 10.72± 3.40ng/mL） （P〈0,01）. Conclusions： sHLA-G may play important roles during the development of preeclampsia, it may be a serum predictor with the development of preeclampsia,

关 键 词：SHLA-G 子痫前期 正常妊娠 

分 类 号：R714.24[医药卫生—妇产科学]