Mechanisms of arteriogenesis  

作　　者：Weijun Cai Wolfgang Schaper 

机构地区：[1]Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China [2]Max-Planck-Institute for Heart and Lung Research, Arteriogenesis Research Group, Bad Nauheim, D-61231, Germany

出　　处：《Acta Biochimica et Biophysica Sinica》2008年第8期681-692,共12页生物化学与生物物理学报（英文版）

基　　金：This work was supported by a grant from the National Science Foundation of China （No. 30771134） and the Kuehl Foundation of Germany

摘　　要：Patients with occlusive atherosclerotic vascular diseases have frequently developed collateral blood vessels that bypass areas of arterial obstructions. The growth of these collateral arteries has been termed ＂arteriogenesis＂, which describes the process of a small arteriole＇s transformation into a much larger conductance artery. In recent years, intensive investigatious using various animal models have been performed to unravel the molecular mechanisms of arteriogenesis. The increasing evidence suggests that arteriogenesis seems to be triggered mainly by fluid shear stress, which is induced by the altered blood flow conditions after an arterial occlusion. Arteriogenesis involves endothelial cell activation, basal membrane degradation, leukocyte invasion, proliferation of vascular cells, neointima formation （in most species studied）, changes of the extracellular matrix and cytokine participation. This paper is an in-depth review of the research critical to recent advances in the field of arteriogenesis that have provided a better understanding of its mechanisms.Patients with occlusive atherosclerotic vascular diseases have frequently developed collateral blood vessels that bypass areas of arterial obstructions. The growth of these collateral arteries has been termed ＂arteriogenesis＂, which describes the process of a small arteriole＇s transformation into a much larger conductance artery. In recent years, intensive investigatious using various animal models have been performed to unravel the molecular mechanisms of arteriogenesis. The increasing evidence suggests that arteriogenesis seems to be triggered mainly by fluid shear stress, which is induced by the altered blood flow conditions after an arterial occlusion. Arteriogenesis involves endothelial cell activation, basal membrane degradation, leukocyte invasion, proliferation of vascular cells, neointima formation （in most species studied）, changes of the extracellular matrix and cytokine participation. This paper is an in-depth review of the research critical to recent advances in the field of arteriogenesis that have provided a better understanding of its mechanisms.

关 键 词：ARTERIOGENESIS shear stress ischemic  remodeling ARTERY 

分 类 号：R543.12[医药卫生—心血管疾病]