钠氢交换蛋白的研究进展  

The Progress in Na^+/H^+ Exchanger

作　　者：曾军英[1] 汤少勋[1] 孙志洪[1] 谭支良[2] 

机构地区：[1]中国科学院研究生院,北京100039 [2]中国科学院亚热带农业生态研究所,长沙410125

出　　处：《细胞生物学杂志》2008年第4期421-424,共4页Chinese Journal of Cell Biology

基　　金：中国科学院知识创新工程重要方向项目(NoKSCX2-YW-N-051);国家自然科学基金(No30600436;No30571352)资助~~

摘　　要：钠氢交换蛋白是一类存在于细胞膜表面的离子转运泵蛋白家族。它负责将细胞内H+与胞外Na+按照1∶1的比例进行交换来调控细胞内pH的动态平衡,影响细胞的容积、运动、分化、凋亡和营养吸收,从而参与许多复杂的生理和病理过程。迄今为止,钠氢交换蛋白家族已发现有9个成员,各亚型间具有结构相似性和组织分布特异性。深入研究NHE的结构、功能及基因表达调控,将为人和哺乳动物的营养生理、疾病治疗提供新的思路和方法。In mammalian eukaryotic cells, the Na^＋/H^＋ exchanger （NHE） is a family of membrane protein that regulates ions fluxes across membranes, which regulates intracellular pH homeostasis by extruding one intracellular proton in exchange for one extracellular sodium. It also plays a key role in the cellular functions including volume regulation, migration, proliferation, differentiation and apoptosis, which involved in a variety of complex physiological and pathological events. To date, The NHE family consists of 9 known isoforms, NHE 1-NHE9, which have homology structure and different tissue distribution. To study the topology, function and gene expression of NHE, it may provide a new way on nutrition regulation, immune enhancement and treating for diseases of human and animal.

关 键 词：钠氢交换蛋白 细胞内pH 拓扑结构 组织分布 基因表达 

分 类 号：R341[医药卫生—基础医学]