替米沙坦对高血压病脉压和CRP、TNF-α、IL-6的影响  

Effects of Telmisartan on Pulse Pressure and Serum CRP, TNF-α, and IL-6 in Patients with Essential Hypertension

作　　者：郑东诞[1] 高修仁[1] 李玉杰[2] 曾群英[1] 

机构地区：[1]中山大学附属第一医院心血管内科,广东广州510080 [2]中山大学附属第一医院急诊科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2008年第5期586-590,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金(06021342)

摘　　要：【目的】检测高血压病患者血浆hs-CRP、TNF-α、IL-6水平,探讨其与脉压的关系、观察其受替米沙坦/HCT和比索洛尔的影响,分析两类药物抗炎和降低脉压作用的差异。【方法】90例高血压病患者和15例健康对照者,检测血浆hs-CRP、TNF-α、IL-6水平;高血压病患者随机分为两组,分别应用替米沙坦/HCT(80mg/12.5mg,qd)和比索洛尔(5mg,qd)治疗6周,观察两亚组患者血压、脉压及血浆hs-CRP、TNF-α、IL-6水平的变化。【结果】和健康对照组比较,高血压病患者血浆炎症因子水平升高[hs-CRP(mg/L)3.4±3.1 vs 1.2±1.6,TNF-α(pg/L)4.5±3.1 vs 1.1±1.3,IL-6(pg/L)187±43 vs 36±11,均P<0.05];高血压病患者分组治疗6周后,替米沙坦/HCT组患者血浆炎症因子水平明显下降,而比索洛尔组无明显变化[降低值hs-CRP(mg/L)1.83±1.67 vs 0.10±1.50,TNF-α(pg/L)2.4±1.9 vs 0.2±1.2,IL-6(pg/L)48±13 vs 12±8,均P<0.05],替米沙坦组脉压的下降较比索洛尔组明显[PP(mmHg)8.5±7.6 vs 2.1±8.9,P<0.05)]。【结论】高血压病患者血浆hs-CRP、TNF-α、IL-6水平升高、可能与脉压有关,替米沙坦/HCT较比索洛尔更明显降低脉压和炎症因子水平。[Objective] To investigate the relationship between serum hs-CRP, TNF-α, IL-6 and artery pulse pressure, the affects on these with Telmisartan/HCT or Bisoprolol in the patients with essential hypertension. To analyze the differences of anti-inflammation effects and lower pulse pressure effects in both medicines. [Methods] Ninteen patients with essential hypertension and 15 healthy control were enrolled. All subjects were drew blood sample to measure the serum concentration of hs-CRP, TNF-α, and IL-6. Ninteen patients were divided into two subgroups at random, and randomized to receive Telmisartan/HCT （ 80 mg/12.5 mg, qd） or Bisoprolol （ 5 mg, qd） for 6 weeks. Changes of blood pressure, pulse pressure, and serum concentration of hs-CRP, TNF-α, and IL-6 were compared in the two subgroups. [Results] The serum concentration of hs-CRP,TNF-α, and IL-6 were higher in the patients with essential hypertension than that in healthy control [ hs-CRP （mg/L） 3.4±3.1 vs 1.2±1.6,TNF- α （pg/L） 4.5 ± 3.1 vs 1.1 ± 1.3, IL-6 （pg/L） 187 ± 43 vs 36 ± 11, all P 〈 0.05]. After 6 weeks treatment, the serum concentration of hs-CRP, TNF-α, and IL-6 in the patients with Telmisartan/HCT were decreased more than that in the patients with Bisoprolol [ hs-CRP（mg/L） 1.83 ± 1.67 vs 0.10 ± 1.50,TNF-α （pg/L） 2.4 ± 1.9 vs 0.2 ± 1.2, IL-6（pg/L） 48 ± 13 vs 12 ± 8, all P 〈 0.05）]. The decreased level of pulse pressure in the patients with Telmisartan/HCT were more than that with Bisoprolol [ PP （mmHg） 8.5 ± 7.6 vs 2.1 ± 8.9, P 〈 0.05 ） ]. [ Conclusions ] There were increased serum concentration of hs-CRP,TNF-α, IL-6 and pulse pressure in the patients with essential hypertension. Telmisartan/HCT were more effective on anti-hypertension and low inflammation factors.

关 键 词：高血压病 脉压 炎症因子 替米沙坦 比索洛尔 

分 类 号：R541.3[医药卫生—心血管疾病]