白细胞介素-1β的表达及间质微血管密度在乳腺浸润性微乳头状癌中的意义  

Significance of interleukin-1β expression and microvascular density in invasive micropapillary carcinoma of breast

作　　者：崔力方[1] 郭晓静[1] 位嘉[1] 刘芳芳[1] 谷峰[1] 范宇[1] 郎荣刚[1] 付丽[1] 

机构地区：[1]天津医科大学附属肿瘤医院乳腺病理科教育部乳腺癌防治重点实验室天津市肿瘤防治重点实验室,300060

出　　处：《中华病理学杂志》2008年第9期599-603,共5页Chinese Journal of Pathology

基　　金：国家自然科学基金资助项目（30470667,30600225）

摘　　要：目的研究白细胞介素（IL）-1β的表达和间质微血管密度在乳腺浸润性微乳头状癌（IMPC）中的意义。方法采用免疫组织化学LSAB法检测100例IMPC、97例浸润性导管癌（IDC）中IL-1β和CD34的表达并计数微血管密度，比较其差异并分析IMPC中IL-1β、CD34的表达与ER、PR、肿瘤细胞增殖指数Ki-67、组织学分级和淋巴结转移等主要病理学特征的关系。结果（1）IMPC中IL-1β的表达与IDC差异无统计学意义（P=0．924）；（2）IMPC中IL-1β的表达与Ki-67的表达（χ^2=7．538，P=0．023）、组织学分级（χ^2=6．556，P=0．038）及淋巴结转移个数（P=0．008）呈正相关，而与ER呈负相关（Z=-2．106，P=0．035）；（3）微血管密度：IMPC组（66．4±15．9）明显高于IDC组（60．0±14．1，t=2．995，P=0．003），且在IMPC中淋巴结转移组（68．8±13．9）显著高于无淋巴结转移组（54．4±20．7，t=-3．459，P=0．001）；IMPC中组织学Ⅱ、Ⅲ级组（68．3±15．0）显著高于Ⅰ级组（59．9±17．6，t=-2．281，P=0．025），而微血管密度与ER、PR、Ki-67表达无相关性。结论IL-1β表达增高、间质微血管密度增加可能是促进乳腺IMPC肿瘤细胞增殖和淋巴结转移的关键因素。[Abstract] Objective To study the significance of interleukin-lbeta （IL-1β） expression and microvascular density （ MVD ） in invasive micropapillary carcinoma （ IMPC ） of breast. Methods Immunohistochmical study for IL-1β and CD34 was performed on 100 cases of IMPC and 97 cases of invasive ductal carcinoma（IDC）. The relationship between IL-1β expression, MVD and various pathologic parameters （estrogen and progesterone receptor status, Ki-67 proliferative index, histologic grade and lymph node metastasis） in IMPC was analyzed. Results There was no significant difference in expression of IL-1β between IMPC and IDC （ P = 0. 924 ）. The expression of IL-1β positively correlated with proliferative index （ P = 0. 023 ）, histologic grade （ P = 0. 038 ） and lymph node metastasis （ P = 0. 008 ）, and negatively correlated with estrogen receptor expression （P = 0. 035 ）. The MVD in IMPC was significantly higher than that in IDC （66. 4 versus 60.0, P = 0. 003）. The mean MVD in node-positive IMPC was higher than that in node-negative IMPC （68.8 versus 54.4, P = 0. 001 ）. In IMPC, the MVD in histologic grade Ⅱ and Ⅲ tumors was much higher than that in histologic grade Ⅰ tumors （68.3 versus 59.9, P = 0. 025）. It had no relationship with hormonal receptor status and proliferative index. Conclusion Overexpression of IL-1β and high microvessel density may have important roles in tumor cell proliferation and lymph node metastasis in IMPC.

关 键 词：乳腺肿瘤 癌 乳头状 白细胞介素1Β 肿瘤转移 

分 类 号：R686[医药卫生—骨科学]