稀土席夫碱邻菲咯啉三元配合物的合成及其生物活性研究  

Synthesis and biological activity of rare earth complexes with schiff base and o-phenanthroline

作　　者：马树芝[1] 何其庄[1] 杨自芳[1] 许东芳[1] 孙大志[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234

出　　处：《化学研究与应用》2008年第9期1138-1142,共5页Chemical Research and Application

基　　金：国家自然科学基金资助项目(20671063);上海市科委纳米技术专项项目(0652nm046)

摘　　要：以稀土氯化物、席夫碱水杨醛缩苯丙氨酸和邻菲咯啉为配体,在无水乙醇溶液中反应,制备了一类新型稀土三元配合物,通过元素分析、摩尔电导、核磁共振、红外光谱、拉曼光谱,确定了该配合物的化学组成:RE(L)(Phen)Cl(H2O)(RE=Ce3+,Sm3+,Eu3+,Y3+,Gd3+;L=席夫碱水杨醛缩苯丙氨酸;Phen=邻菲咯啉)。通过抗菌实验对其抑菌效果进行研究,结果表明配合物对大肠杆菌、金黄色葡萄球菌及白色念珠菌都有较强的抑制作用,抗菌谱广;用流式细胞检测法对配合物使癌细胞凋亡能力做了初步研究,证明其具有使癌细胞凋亡的效果。New solid ternary complexes of the rare earth ions with o-Phenanthroline （Phen） and Schiff base salicylaldehyde- L- Phenylalanine （KHL）were synthesized in ethanol solution. Their compositions were characterized by elemental analysis, molar conductance,lHNMR,FT-IR and Raman. The compositions of the complexes were confirmed to be RE（L） （Phen） CI （H2O）. （Ce3＋, Sin3＋, Eu3＋, Y3＋ , Gd3＋ ）. The antibacterial activities testing indicates that all these solid ternary complexes have antibacterial ability against Escherich coli, Staphy lococcus anreus, Candida albican. The antimicrobial spectrum of the complexes are. broad. Flow cytometry was used to study the complex ability of anticancer, which indicates that the cancer cells were withered by the complex.

关 键 词：树枝状大分子 己二胺 丙烯酸甲酯 破乳性能 

分 类 号：O612.3[理学—无机化学]