基于链状氨基酸N-手性季铵盐合成中的取代反应研究  

A substituted reaction in the synthesis of N-chiral quaternary ammonium salts based on linear amino acid

作　　者：吴划方[1] 冯春[2] 陈晓珍[2] 林文彬[2] 罗应刚[2] 潘鑫复[1] 

机构地区：[1]兰州大学化学化工学院,功能有机分子化学国家重点实验室,甘肃兰州730000 [2]中科院成都生物研究所,四川成都610041

出　　处：《化学研究与应用》2008年第9期1220-1223,共4页Chemical Research and Application

基　　金：国家自然科学基金(20672108)资助项目

摘　　要：In the synthesis N-chiral quaternary ammonium salts from(2S)-N-benzyl-N-methyl-L-tyrosine methyl ester and(3S)-N-methyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester,a substitution occur even with 1.0 eq allyl bromide.That is the benzyl and methyl are removed respectively,and two allyl are attatched,and the compounds are analyzed and characterized by IR,1H NMR,13C NMR and MS methods.In the synthesis N-chiral quaternary ammonium salts from （23）-N-benzyl-N-methyl-L-tyresine methyl ester and （3S）-N- methyl-1,2,3,4-tetrahydm-isoqninoline-3-carboxylic acid methyl ester,a substitution occur even with 1.0 eq aUyl bromide. That is the benzyl and methyl are removed respectively, and two allyl are attatched, and the compounds are analyzed and characterized by IR,1H NMR,13C NMR and MS methods.

关 键 词：N-手性季铵盐 合成 取代 

分 类 号：O623.738[理学—有机化学]