红景天苷对骨髓抑制贫血小鼠造血祖细胞增殖的影响  

Effect of Salidroside on Proliferation of Hematopoietic Progenitor Cell in Myelosuppressed Anemia Mice

作　　者：张新胜[1] 王雁北[2] 祝彼得[3] 程秋妍[1] 

机构地区：[1]河南师范大学生命科学学院,河南新乡453007 [2]河南师范大学体育学院 [3]成都中医药大学基础医学院

出　　处：《四川动物》2008年第5期926-928,共3页Sichuan Journal of Zoology

摘　　要：采用造血祖细胞培养技术,观察红景天苷体内给药和细胞培养直接用药对骨髓抑制贫血小鼠造血祖细胞增殖和骨髓有核细胞数目的影响。结果显示,体内用药能显著增加BMC数目,促进BFU-E、CFU-E、CFU-GM和CFU-Meg集落形成(P<0.05);在一定浓度下,体外用药也能显著促进BFU-E、CFU-E、CFU-GM和CFU-Meg集落形成(P<0.05)。结果提示,红景天苷可能通过间接或直接作用刺激骨髓抑制贫血小鼠造血祖细胞的增殖来促进造血功能的恢复。Hematopoietic progenitor cell culture was used to observe the effect of salidroside on the proliferation of hematopoietic progenitor cell and the number of bone marrow cells in myelosuppressed anemia mice. The results showed that salidroside could significantly increase the number of bone marrow ceils, promote the formation of burst-forming unit erythroid （BFU-E）, colony-forming unit erythroid （CFU-E）, colony-forming unit-granulocyte macrophage （CFU-GM） and colony- forming unit-megakaryocte（CFU-Meg） in vivo（P 〈0.05）. In certain concentration, salidroside could also significantly promote the formation of BFU-E, CFU-E, CFU-GM and CFU-Meg in vitro （P 〈 O. 05）. It suggested that salidroside may promote the recovery of hematopoietic function of myelosuppressed anemia mice by stimulating the proliferation of hematopoietic progenitor ceils in indirect or direct way.

关 键 词：红景天苷 骨髓抑制 造血祖细胞 

分 类 号：R285.5[医药卫生—中药学] Q95-33[医药卫生—中医学]