皮质酮对大鼠再生肝鸟氨酸脱羧酶及抗酶基因表达的影响  

Effect of Corticosterone on Ornithine Decarboxylase and Antizyme Gene Expression in Rat Regenerating Liver

作　　者：索世英[1] 曹兰菊[2] 马建敏[1] 宁黔冀[1] 

机构地区：[1]河南师范大学生命科学学院,河南新乡453007 [2]河南师范大学体育学院

出　　处：《四川动物》2008年第5期937-938,共2页Sichuan Journal of Zoology

基　　金：河南省科技厅攻关项目(0624410108)

摘　　要：以部分肝切除诱导的雄性SD大鼠(180～200g)早期再生肝为材料,用RT-PCR法分析皮质酮处理后再生肝鸟氨酸脱羧酶及抗酶mRNA水平变化。结果表明,皮质酮对鸟氨酸脱羧酶mRNA水平具有剂量依赖性抑制作用;10、20mg/kg体重皮质酮对抗酶mRNA水平影响不大,40mg/kg处理可促进其转录。The male SD rats （180 -200 g） were used to investigate the effect of corticosterone on ornithine decarboxylase （ODC） and antizyme mRNA levels in early regenerating liver induced by partial hepatectomy with RT-PCR. Results indicated that corticosterone inhibited dose-dependently the level of ODC mB.NA. The effects of 10 mg/kg and 20 mg/kg body weight corticosterone on antizyme mRNA expression were not obvious, however, 40 mg/kg corticosterone treatment could stimulate antizyme gene transcription.

关 键 词：皮质酮 鸟氨酸脱羧酶 抗酶 再生肝 

分 类 号：Q4[生物学—生理学]