R-(＋)-硫代四氢呋喃-2-甲酸的制备  

Synthesis of R-(+)-thiotetrahydrofuran-2carboxylic acid

作　　者：李娟[1] 李显林[1] 胡铁军 雷江[3] 

机构地区：[1]沈阳第一制药厂,辽宁沈阳110023 [2]东北制药总厂,辽宁沈阳110024 [3]沈阳中海生物技术开发有限公司,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2008年第9期714-715,共2页Journal of Shenyang Pharmaceutical University

摘　　要：目的制备R-(+)-硫代四氢呋喃-2-甲酸。方法以四氢呋喃-2-甲酸为原料,经拆分、氯代、取代3步反应得到R-(+)-硫代四氢呋喃-2-甲酸。结果反应总收率为29%,产物结构经1H-NMR和MS确证。结论通过实验摸索了一条制备光学纯度的R-(+)-硫代四氢呋喃-2-甲酸的路线,该方法简单、易于操作。Objective To prepare R-（＋）-thiotetrahydrofunan-2-carboxylic acid. Method R-（＋）- thiotetrahydrofuran-2-carboxylic acid was synthesized from tetrahydrofuran-2-carboxylic acid via three steps： resolution, chlorination and displacement. Results The total yield was 29% and the structure of desired compound was confirmed by 1H-NMR and MS. Conclusions The new route for synthesis of R-（＋）-thiotetrahydrofuran-2-carboxylic acid is developed, and the process is easy to operate.

关 键 词：R-(+)-硫代四氢呋喃-2-甲酸 四氢呋喃-2-甲酸 合成 

分 类 号：R135.1[医药卫生—劳动卫生] R446.122[医药卫生—公共卫生与预防医学]