红人归胶囊治疗更年期综合征作用机制初探  

Action mechanisms of Hongrengui capsules on climacteric syndrome

作　　者：王芳[1] 张亚宏[2] 左代英[2] 吴英良[2] 

机构地区：[1]沈阳药科大学图书馆,辽宁沈阳110016 [2]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2008年第9期739-743,共5页Journal of Shenyang Pharmaceutical University

摘　　要：目的进行红人归胶囊(HRG)治疗更年期综合征机制的研究。方法采用去势雌性(ovariec-tomized,OVX)大鼠作为更年期动物模型,放射性免疫法测定OVX大鼠血清雌二醇含量,高效液相色谱-电化学检测法测定下丘脑单胺神经递质及其代谢产物的含量,并测定其免疫器官的脏器系数。结果HRG可使OVX大鼠血清雌二醇含量升高,使下丘脑升高的5-羟色胺(5-HT)及其代谢产物5-羟色胺酸(5-HIAA)含量明显下降,显著提高去甲肾上腺素(NE)和多巴胺(DA)含量,使升高的5-HT含量与NE含量的比值降低至接近正常;HRG能提高OVX大鼠胸腺系数和脾系数。结论HRG通过调节植物神经功能、生殖内分泌系统和免疫功能,多层次、多途径、多环节地作用于更年期衰退的神经内分泌免疫网络,从而起到稳定机体内环境,缓解更年期症状的作用。Objective To study the action mechanisms of Hongrengui capsules （HRG, traditional Chinese medicine）. Method Ovariectomized rats as climacteric syndrome model were used to study the effects of HRG on serum estradiol level by radio-immunoassay and on hypothalamic monoamine neurotransmitters contents by high performance liquid chromatography and electrochemical detector. Adrenal gland index and thymus index were also determined. Result It was found that HRG could increase the contents of serum estradiol in OVX rats. HRG could reduce the contents of hypothalamic 5-HT and 5-HIAA, which were increased in OVX rats. And it could increase the contents of NE and DA of hypothalamus in OVX rats. HRG could also improve the function of immunity. Conclusions HRG can produce effects on declined neuroendocrine-immune network in OVX rats from various levels, ways and links by means of regulating the function of plant nerve and reproduction endocrine and immunity. So it can stabilize inner condition of body and relieve symptoms of climacteric syndrome.

关 键 词：更年期综合征 红人归胶囊 去势大鼠 神经内分泌免疫调节 

分 类 号：R96[医药卫生—药理学]