产ESBLs肺炎克雷伯菌和大肠埃希菌耐药性分析  

Antibiotic resistance of extended-spectrum β-Lactamases in klebsiella pneumoniae and Escherichia Coli

作　　者：任志强[1] 刘丽君[1] 郭利民[1] 肖科武[1] 江维[1] 

机构地区：[1]湖南省益阳市中心医院,湖南益阳413000

出　　处：《中南药学》2008年第5期630-632,共3页Central South Pharmacy

摘　　要：目的分析产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌、大肠埃希菌的耐药性,指导临床合理用药。方法采用API鉴定系统进行菌株鉴定及药敏试验。结果2种细菌ESBLs总阳性检出率为60.2%(153/254);肺炎克雷伯菌ESBLs为60.2%(53/88);大肠埃希菌为60.2%(100/166);产ESBLS菌株对青霉素类和头孢类抗菌药物大多耐药,仅对美罗培南非常敏感,产ESBLs菌株对抗菌药物的耐药率高于非产ESBLs菌株。结论医院及时监测产ESBLs菌的发生率及其耐药趋势以指导临床用药至关重要。Objective To investigate the antibiotic resistance of Escherichia Coli and Klebsiella pneumonia producing extended-spectrum β-1actamases （ESBLs） and to guide the clinical administration of drugs. Methods API half-automicroscan system was used to identify the pathogenic bacteria and conduct drug resistance test. Results The detection rate for ESBLs was 60.2% in both E. Coli and K. pneumoniae, 60.2%（53/88） in K. pneumonia and 60.2% （100/ 166） in E. coli. ESBL producing strains were more resistant to penicillins and cephalosporins, but sensitive to meropenem. The resistance rate of ESBL producing strains to antibacterial agents was higher than that of non-ESBL producing strains. Conclusion Detecting ESBI, strain producing rate and their susceptibility to antibiotics is are very important in guiding the clinical administration of drugs.

关 键 词：产超广谱Β-内酰胺酶 肺炎克雷伯菌 大肠埃希菌 

分 类 号：R969.3[医药卫生—药理学]