镉作业工人尿镉和尿蛋白变化的检测分析  

Detection and Analysis on Changing of the Urinary cadmium and Urinary Protein in Cadmium-exposed Workers

作　　者：周丽[1] 徐新云[1] 杨荣兴[1] 

机构地区：[1]广东省深圳市疾病预防控制中心,518020

出　　处：《职业与健康》2008年第19期2012-2013,共2页Occupation and Health

基　　金：深圳市科技局资助课题(编号200702135)

摘　　要：目的探讨镉对作业工人尿镉、尿β2-微球蛋白和视黄醇结合蛋白的影响。方法用原子吸收法检测尿镉和空气中镉水平,用ELISA方法测定尿β2-微球蛋白和视黄醇结合蛋白。结果受检对象中尿镉水平(μg/g肌酐)的分布情况是:0～有86人,2～有145人,3～有182人,4～有159人,>5有80人。其中2人不仅尿镉超标而且β2-微球蛋白达到慢性轻度镉中毒水平。工作场所空气中镉浓度0.005～0.16mg/m3,样品超标率33.3%。结论镉作业可引起部分接触者尿镉和尿β2-微球蛋白水平发生改变,是评价镉毒性作用的重要指标。[ Objective] To detect and analyze the urinary cadmium, urinary proteins and retinol-binding protein among the workers exposed to cadmium. [ Methods] The urinary cadmium among workers and cadmium concentrations in the workplace air were detected by atomic absorption speetrophotometry. The urinary 132 microglobulin and retinol-binding protein were tested by ELISA. [ Results] The distribution of urinary cadmiums in all workers exposed to cadmium show that 86 workers was in 0 - , 145 workers was in 2 - , 182 workers was in 3 - , 159 workers was in 4 - , and 80 workers was in 〉 5 . The urinary cadmiums of 2 workers were over the limit and their 132 microglobulin reached chronic poisoning level. The cadmium concentrations in the workplace air were 0. 005 - 0.16 mg/m^3, 33.3% of samples were higher than the national health standard. [ Conclusion] The urinary cadmiums and urinary 132 mieroglobulin of some workers would be changed by exposure to cadmium, which were the important indexes for assessment of cadmium hazardous effect.

关 键 词：镉接触 尿镉 尿蛋白 

分 类 号：R135.1[医药卫生—劳动卫生]