长效纳曲酮缓释剂治疗阿片依赖者情绪反应的事件相关电位研究  

The ERP study on the effective of LSRNTX treatment for opioid dependences on their emotion

作　　者：何胜昔[1] 于龙川[2] 王冬梅[3] 胡疏[1] 贾少微[1] 

机构地区：[1]北京大学深圳医院核医学科,深圳北京大学香港科技大学医学中心,深圳518036 [2]北京大学生命科学院 [3]中国科学院心理研究所

出　　处：《中国行为医学科学》2008年第9期796-798,共3页Chinese Journal of Behavioral Medical Science

基　　金：广东省科技计划项目（2004B36001075）;广东省医学科学基金项目（A2007592） 志谢 本项目得到湖北省公安厅禁毒总队干永平总队长、湖北省禁毒委员会办公室王代松主任、武汉公安强制戒毒所孙家富主任、解放军193医院自愿戒毒所乔石主任、武汉市和平自愿戒毒昕鲁保忠所长孙志俊医师、武汉市康九自愿戒毒所的伍望桥主任文锐光医师、常德市第五人民医院自愿戒毒所的彭剑汉所长、深圳市思沃生命科技有限公司的尹述贵主任药师等的支持和帮助,在此表示衷心的谢意

摘　　要：目的用事件相关电位（ERP）技术研究长效纳曲酮缓释剂（LSRNTX）植入治疗对调节阿片类药物依赖患者情绪感受能力的作用。方法现场采集记录3组不同戒毒方式的阿片类药物依赖患者和正常对照组由3组不同情绪内涵的图片诱发的ERP波形。结果①LSRNTX治疗组植入6个月以上者中性图片诱发的P200波形的潜伏期为（197．27±41．30）ms，正常对照组为（196．36±42．50）ms，两者差异无显著性（P〉0．05）；而强制戒毒组为（213．91±37．18）ms，阿片类药物依赖对照组组为（216．00±41．52）ms，与正常对照组比较差异有显著性（P〈0．01）；②正性情绪图片的源定位分析发现，正常对照组P200源发生点在大脑前额叶皮质，LSRNTX治疗者的在内侧前额叶皮质后部；强制戒毒组和阿片类药物依赖对照组均在扣带回后部。结论LSRNTX能使患者情绪感受产生的恼电ERP波形倾向正常化，正性图片诱发的P。的神经定位由阿片类药物依赖患者的扣带回升高至内侧前额叶皮质。Objective To explore the effective of long-term sustained release naltrexone （LSRNTX） treatment for opioid dependences on their emotion. Methods The patients were divided into three groups ： LSRNTX treatment group,incarcerated abstinent group and opioid dependence control group, and adding on healthy control group. Without any overt response on each picture subjects all were recorded scalp ERP when they saw three blocks pictures,including positive happy pictures, negative mutilated bodies, and neutral stinmli. Results Firstly, the latency of P200 elicited by neutral pictures in the group treated with LSRNTX over 6 months was（ 197.27 ± 41.30） ms and healthy control was （196.36 ± 42.50）ms, which showed no significant different between two groups （ P 〉 0. 05 ）. But incarcerated abstinent group and opioid dependence control group showed a significantly worse condition （P〈0.01）. Secondly,BESA results on happy pictures P200 showed that sources of P200 in healthy control group were located at prefrontal cortex, LSRNTX treatment group at medial prefrontal cortex,incarcerated abstinent group and opioid dependence control group both at posterior cingulate cortex. Conclusion Present study proved that LSRNTX implants group could lead to significantly better psychological conditions than incarcerated abstinent group and non-treating group. After LSRNTX implant treatment, the patients showed a trend toward normalization of neuronal function.

关 键 词：长效纳曲酮缓释剂 阿片类药物依赖 情绪 事件相关电位 

分 类 号：R749.6[医药卫生—神经病学与精神病学]