腰腿理痛散对大鼠硬膜外移植自体髓核脊神经节损伤的组织学研究  

STUDY ON EFFECT OF YAOTUI LITONG POWDER ON HISTOLOGY CHANGES OF RATS' SPINAL GANGLION INJURY CAUSED BY AUTOGRAFT NUCLEUS PULPOSUS TO CAVITAS EPIDURALIS

作　　者：潘建西[1] 张思胜[1] 谈明顺 王临青 

机构地区：[1]甘肃省兰州市城关区中医骨伤科医院,兰州730010 [2]兰州市西固区中医院,兰州730060

出　　处：《中国中医药科技》2008年第5期331-332,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：甘肃省中医药科研项目No.05-GZK-L-01

摘　　要：目的:观察腰腿理痛散对大鼠硬膜外移植自体髓核脊神经节损伤的组织学改变的影响。方法:取健康Wistar大鼠50只,随机分为假手术组、模型组、阴性对照组、高剂量组、低剂量组,每组10只,将大鼠自身的尾椎髓核取出移植于左侧硬膜外腔L5、L6神经根背侧,造成非压迫性大鼠自体髓核移植硬膜外模型,并观察2周时脊神经节组织形态学变化。结果:造模各组脊神经节均有明显的组织形态学改变,但用药组的损伤程度较模型组轻。结论:腰腿理痛散有减轻非机械压迫性髓核对脊神经节损伤作用。Objective:To observe the effect of yaotui litong powder on histology changes of rats' spinal ganglion injury caused by autograft nucleus pulposus to cavitas epiduralis.Methods:50 rats were divided into five groups,sham operated,model,yaotongning,low and high dose yaotui litong powder groups.Autogenous nucleus pulposus was removed from coccygeal vertebral and placed into the back of L5～6 nerve roots of left cavitas epiduralis.The non-compressive models with transplanted autogenous nucleus pulposus were made,the histology changes of rats' spinal ganglion were observed in each group after two weeks.Results:The significant histology changes of rats' spinal ganglion in each group except sham operated group were observed,but which in the yaotongning and yaotui litong powder groups were obviuosly lighter.Conclusion:Yaotui litong powder can protect spinal ganglion from injury caued by autograft nucleus pulposus to cavitas epiduralis.

关 键 词：腰椎间盘突出症/中医药疗法 @腰腿理痛散/治疗应用 椎间盘突出症/病理学 大鼠 

分 类 号：R285.5[医药卫生—中药学]