卵巢高反应对体外受精-胚胎移植的影响  

Impact of ovarian hyper-response to gonadotropin stimulation on the pregnancy outcome of in vitro fertilization and embryo transfer

作　　者：陈小琴[1] 李予[1] 张清学[1] 王文军[1] 麦美琪[1] 陈向红[1] 陈静华[1] 杨冬梓[1] 

机构地区：[1]中山大学附属第二医院生殖中心,510120

出　　处：《中国妇产科临床杂志》2008年第5期343-345,358,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的探讨体外受精-胚胎移植周期控制性超排卵(COH)中卵巢高反应对妊娠结局的影响。方法回顾性分析中山大学附属第二医院生殖中心1082个IVF/ICSI周期的临床资料,根据HCG注射日血E2>11010pmol/L或获卵数>15个定义为高反应组,HCG注射日血E2>1835pmol/L,且获卵数5～15个为正常反应组,比较两组的妊娠结局。结果与正常反应组相比,高反应组获得的优质胚胎数显著增多(P<0.001),但两者的受精率、卵裂率、胚胎种植率、临床妊娠率、流产率比较,差异无显著性(P>0.05)。结论COH中卵巢高反应对妊娠结局无明显影响,但需注意预防卵巢过度刺激综合征的发生。Objective To investigate the impact of ovarian hyper - response to gonadotropin on pregnancy outcome during controlled ovarian hyperstimulation （COH） with GnRH agonist and FSH in IVF/ICSI cycles. Methods This retrospective study on 1 082 IVF/ICSI cycles performed in our reproductive center compared pregnancy outcomes between high responder group, e.g. peak E2〉11 010 pmol/L on the day of HCG administration or 〉15 retrieved oocytes, and normal responder group, e.g. 1 835 pmol/L 〈peak E2〈11 010 pmol/L on the day of HCG administration and 5-15 retrieved ooeytes. Results High responders achieved more high - quality embryos. But no statistically significant differences in fertilization rate, cleavage rate, implantation rate, pregnancy rate, miscarriage rate was found between the two groups. Conclusions High response of ovary to gonadotropin stimulation does not affect IVF/ICSI outcome, but precaution should be taken to prevent OHSS.

关 键 词：卵巢高反应 体外受精-胚胎移植 妊娠 

分 类 号：R714.8[医药卫生—妇产科学]