硒水平与中国农村老年人群认知能力研究  

Research on Correlation between Selenium Level and Cognitive Function for Rural Elderly Population in China.

作　　者：金银龙[1] 梁超轲[1] 吉荣娣[1] 曹静祥[1] 马凤[1] 应波[1] 程义斌[1] 边建朝[2] 李平[3] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100050 [2]山东省地方病防治研究所 [3]四川省疾病预防控制中心

出　　处：《医学研究杂志》2008年第9期19-23,共5页Journal of Medical Research

基　　金：美国NIH(R01 AG019181)

摘　　要：目的硒是与抗氧化酶的活性有关的微量元素,被认为是一种通过增强酶的活性来拮抗自由基的保护剂。关于硒与阿尔茨海默病(AD=Alzheimer’s Disease,或称Dementia)的关系研究结果不一致。为此,进行了硒水平与中国农村老年人群认知能力研究。方法研究对象为中国四川和山东两省四县市的2000名≥65岁老年人群,当地出生并在当地居住。采用环境流行病学方法,调查研究了老年人群认知能力、APOE基因、指甲硒与血液硒,以及环境食物硒和老年人群日摄硒量。相关系数、方差模型和协方差多因素模型应用于硒水平与认知记分的统计分析。结果分析结果指出硒水平与老年人群认知能力二者之间有明显的正相关,并呈现剂量-反应关系。结论中国农村老年人群稳定的硒暴露水平研究,支持了终身低硒水平与低认知能力相关的假设。Objective Selenium is a trace element associated with antioxidant activity and is considered to be a protective agent a- gainst free radicals through enhanced enzyme activity. Studies on selenium and cognitive function or Alzbeimer＇ s disease have yielded in- consistent results. Therefore, correlation between selenium level and cognitive function for rural elderly population in China was conducted. Methods A cross - sectional survey of 2,000 rural Chinese aged 65 years or older from two provinces in China was conducted using of the Community Screening Instrument for Dementia by environmental epidemiology study. APOE gene, selenium levels in food, blood and nail samples were analyzed. Correlation coefficients, analysis of variance models and multivariate analysis of covariance models were used to estimate the association between selenium levels and cognitive test scores. Results Lower selenium levels measured were significantly associated with lower cognitive scores. A dose - response effect of selenium was also seen for those significant associations. Conclusion This geographically stable cohort support the hypothesis that a lifelong low selenium level is associated with lower cognitive function.

关 键 词：硒水平 农村老年人群 认知能力 老年痴呆症社区调查表 阿尔茨海默病 协方差多因素模型分祈 

分 类 号：R161.7[医药卫生—公共卫生与预防医学] R749.16