男性不育因素分析  

Factor analysis on male infertility

作　　者：白婷[1] 肖红梅[1] 卢光琇[1] 

机构地区：[1]中南大学湘雅医学院生殖与干细胞工程研究所中信湘雅生殖与遗传专科医院,长沙410078

出　　处：《国际病理科学与临床杂志》2008年第4期287-290,共4页Journal of International Pathology and Clinical Medicine

基　　金：湖南省卫生厅科研基金(B2004-006)~~

摘　　要：目的:分析不孕不育中的男性因素。方法:收集3 777对不孕夫妇的孕产史及不孕不育病因检查结果,对男性不育患者资料进行分析,包括男性生殖专科体格检查、精液常规分析、遗传学检查等。结果:单纯男性因素不育患者1 406例,占总数的37.23%。其中无精子症在男性不育患者中占57.99%,少弱精子症及严重少弱精子症占37.34%。在无精子症及严重少弱精子症患者中,染色体异常表现有数目异常和涉及大多数染色体在内的结构异常。结论:男性因素是不孕症病因中重要的组成部分,影响男性生育的相关基因可能存在于性染色体和大部分常染色体上。Objective To explore the male factors in infertility. Methods Data of 3 777 infertile couples were collected. Data of infertile men were analyzed, including male physical examination, semen fetation and gene tests. Results One thousand four hundred and six infertile couples were caused by simple male factors, occupied 37.23% in all patients. Azoospermia occupied 57.99% in infertile men. Then was oligo-asthenospermic and severe oligo-asthenospermic patients, occupied 37.34%. In azoospermia and severe oligo-asthenospermic patients, chromosome abnormality showed numerical abnormalities and structural abnormalities which involved in most chromosomes. Conclusion Male factors are an important part of infertility causes. The related gene may existed in sex chromosomes and mostly euchromosomes.

关 键 词：不孕症 男性不育 病因 遗传因素 

分 类 号：R698.2[医药卫生—泌尿科学]