脂肪组织巨噬细胞浸润与胰岛素抵抗  

Macrophage infiltration in adipose tissue and insulin resistance

作　　者：郭彩红[1] 袁莉[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,武汉430022

出　　处：《国际内分泌代谢杂志》2008年第5期329-331,共3页International Journal of Endocrinology and Metabolism

基　　金：湖北省自然科学基金资助项目（2005ABA185）

摘　　要：肥胖是一种低度炎性反应状态。近年来发现肥胖个体脂肪组织中巨噬细胞的浸润显著增加，并有研究表明脂肪组织的炎性反应因子主要由浸润的巨噬细胞分泌。目前对脂肪组织巨噬细胞的来源以及影响其浸润的因素还有争论。研究发现，巨噬细胞可以通过抑制脂肪细胞分化，增加炎性反应因子的表达等导致胰岛素抵抗的发生、发展。Obesity is a chronic state of inflammation. In recent years,researches have showed that maerophage infiltration of adipose tissue in obese individuals was increased and macrophages were the primary source of many inflammatory factors. Currently,it is not clear what causes increased macrophage infiltration of adipose tissue in obese individuals. The present researches showed that macrophages can inhibit the differentiation of adipocyte, and increase the expression of the inflammatory cytokines. The macrophage infiltration of adipose tissue played an important role in the development of insulin resistance.

关 键 词：巨噬细胞 脂肪组织 炎症 肥胖 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]