过氧化氢酶与糖尿病的研究进展  

Catalase and diabetes mellitus

作　　者：赵瑞娥[1] 刘丽梅[1] 

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病研究所,200233

出　　处：《国际内分泌代谢杂志》2008年第5期336-338,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（39900071）

摘　　要：过氧化氢酶（CAT）能迅速将超氧化物歧化酶分解过氧化物产生的过氧化氢（H2O2）转化为氧气和水，从而减少更具氧化活性的羟自由基生成，防止氧化应激造成的胰岛β细胞损伤和功能异常。研究发现，CAT基因的两个多态位点C-262T及C1167T均与糖尿病发生显著相关，其C等位基因均为1型糖尿病发病的危险因子。此外，其他种族研究证实，CAT的遗传学缺陷及其基因多态性均可引起CAT活性下降，使机体H2O2浓度增加，加重氧化应激。提示CAT的遗传变异可能是促进糖尿病及其并发症发生和发展的重要病理生理机制之一。Catalase （CAT） can decompose hydrogen peroxide （H2O2 ）, a product of peroxide dismuted by superoxide dismutase,into oxygen and water, so as to reduce the generation of toxic reactive hydroxyl radicals and prevent damage and dysfunction of islet β cells. Previous studies have shown that two polymorphisms,C- 262T and Cl167T, of CAT gene were significantly associated with diabetes mellitus, and that their C alleles were risk factors of type 1 diabetes mellitus. Moreover, other ethnical studies demonstrated that both genetic defects and polymorphisms of the CAT gene could reduce the activity of CAT,increase the concentration of the H2O2 and therefore aggravate the oxidative stress. These data suggested that genetic variation of CAT may be an important pathophysiological mechanism in the development of diabetes and its complications.

关 键 词：过氧化氢酶 氧化应激 糖尿病 

分 类 号：R587[医药卫生—内分泌]