二仙养骨汤合福善美对绝经后骨质疏松症骨钙素、降钙素及骨密度水平的影响  

CLINICAL OBSERVATION ON THE INFLUENCE OF ERXIANYANGGUTANG AND FOSAMAX TO THE IEVELS OF BONE GLA PROTEIN,CALCITIONIN AND BONE DENSITY IN POSTMENOPAUSAL OSTEOPOROSIS

作　　者：黄建华[1] 陈金春[2] 黄建武[1] 王丽[1] 林爱菊[1] 

机构地区：[1]浙江省温州医学院附属第三医院,瑞安325200 [2]浙江省瑞安市人民医院分院

出　　处：《中医正骨》2008年第9期4-6,共3页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：浙江省中医药科技项目2007CB203

摘　　要：目的:研究二仙养骨汤合福善美治疗绝经后骨质疏松症骨钙素、降钙素及骨密度水平的变化。方法:将67例绝经后骨质疏松症随机分为治疗组(34例)和对照组(33例),两组同时服用福善美,治疗组加服二仙养骨汤,均经6个月治疗,观察两组治疗前后骨钙素、降钙素和骨密度值,并进行统计学分析。结果:治疗组和对照组治疗前后的骨密度T分数分别为-3.72±0.84,-2.04±0.66和-3.69±0.83,-2.95±0.77,差值分别为-1.68±0.83和-0.74±0.34。治疗组和对照组治疗前后骨钙素分别为48.91±8.63、28.65±11.54和46.22±12.51、43.80±12.71,差值分别为22.64±7.03和11.84±9.52;降钙素分别为32.04±9.67、53.72±11.84和48.95±6.77、51.61±9.65,差值分别为12.68±7.83和2.74±0.34。比较治疗组治疗前后骨密度T值、骨钙素和降钙素水平差异均有统计学意义(P<0.05);对照组治疗前后骨密度T值差异亦有统计学意义(P<0.05),而骨钙素和降钙素差异则无统计意义(P>0.05);两组治疗前后的骨钙素和降钙素差值比较,差异均有统计学意义(P<0.05)。结论:二仙养骨汤合福善美治疗绝经后骨质疏松症使降钙素的水平明显升高,骨钙素水平明显降低,提高了绝经后骨质疏松症的临床疗效。Objective:To observe the influence of ERXIANYANGGUTANG(EXYGT,a TCM composition)and Fosamax to changes on the lev-els of bone gla protein(BGP),calcitionin(CT)and bone mineral density(BMD)in postmenopausal osteoporosis(PMO).Methods:67 cases of patients with PMO were randomly divided into two groups,group A(therapy group,34 cases,EXYGT and Fosamax used)and group B(control group,33 cases,Fosamax for use).Both of them were cured for six months,then values of BGP,CT and BMD in two groups pre-and posttreat-ment were observed and analyzed statistically.Result:In two groups,T scores of BMD pre-and posttreatment were respectively-3.72 ± 0.84,-2.04±0.66 and-3.69 ± 0.83,-2.95 ± 0.77,the difference were respectively-1.68 ± 0.83 and-0.74±0.34.Also the numbers above of BGP were respectively 48.91 ± 8.63、28.65 ± 11.54 and 46.22± 12.51、43.80± 12.71,the difference were 22.64±7.03 and 11.84 ±9.52.on CT,they were 32.04±9.67、53.72± 11.84 and 48.95±6.77,51.61±9.65,the difference were 12.68 ± 7.83和2.74 ± 0.34.There had statistical significance on difference of BMD' s T score,BGP and levels of CT pre-and post-treatment in group A(P<0.05),in group B the same were seen on T score of BMD(P<0.05),but not on BGP and CT(P<0.05).In two groups on BGP and CT pre-and post-treat-ment,there had statistical significance on difference(P<0.05).Conclusion:The method of EXYGT and Fosamax used to cure PMO could obvi-ously heighten the levels of CT,degrade that of BGP and elevate clinically curative effect of PMO.

关 键 词：绝经后骨质疏松症/治疗 二仙养骨汤/药效学 福善美 骨钙素 降钙素 骨密度 临床研究 

分 类 号：R580[医药卫生—内分泌]