药物缓释用生物降解性高分子载体材料的研究  

Review on biodegradable polymer carrier for drug sustained release

作　　者：王改娟[1] 周志平[1] 盛维琛[1] 

机构地区：[1]江苏大学材料学院,江苏镇江212013

出　　处：《弹性体》2008年第4期63-66,共4页China Elastomerics

基　　金：国家自然科学基金资助项目(20774038)

摘　　要：生物降解性聚合物安全、可靠,有良好的生物相容性,可通过生理途径代谢排出体外,成为了药物载体的首选材料。本文简要综述了主要常用天然和合成生物降解性聚合物,如壳聚糖、环糊精、胶原、聚乳酸、聚酸酐、氨基酸类聚合物的制备方法,在药物缓释体系的作用和效果,并对其发展趋势进行了展望。Biodegradable polymers are the first choice for drug carrier material because they are secure, reliable, good biocompatibility and excreted through physiologicalmeans such as metabolism. This article gave a brief overview on the main common natural and synthetic biodegradable polymer such as chitosan, cyclodextrin, collagen, polylactic acid, polyanhydride, amino acid type of polymer. We discuss their function and effect on drug delivery system applications. At last, we have an outlook on its development trends.

关 键 词：生物降解性 聚合物 缓释材料 制备方法 

分 类 号：TQ460.34[化学工程—制药化工]