剖宫产术对乙肝病毒母婴传播的阻断作用观察  

Blocking effect of cesarean section on the mother-to-child hepatitis B virus (HBV) transmission

作　　者：何志毅[1] 杨德桂[1] 梁顺银[1] 胡淑君[1] 

机构地区：[1]广州医学院第一附属医院,广东广州510120

出　　处：《山东医药》2008年第15期10-11,共2页Shandong Medical Journal

基　　金：广东省科技计划项目(2007B030501013)

摘　　要：目的观察剖宫产术对乙型肝炎病毒(HBV)母婴传播的阻断作用。方法选择174例乙型肝炎病毒携带、肝功能正常的孕妇为研究对象,孕妇常规产前(孕7、8、9月时)注射乙型肝炎人免疫球蛋白200IU,共3次,分别检测孕妇静脉血及其分娩的新生儿脐血、静脉血的HBVM及HBV-DNA,根据不同分娩方式进行分析对照。结果双阳且HBV-DNA(+)孕妇阴道分娩所生新生儿双阳且HBV-DNA(+)率为41.67%,剖宫产所生新生儿为6.67%,两组相比,P<0.05;双阳且HBV-DNA(-)孕妇阴道分娩所生新生儿双阳且HBV-DNA(+)率为5.88%,剖宫产所生新生儿为7.69%,两组相比P>0.05。结论剖宫产可降低HBV双阳携带且HBV-DNA阳性孕妇所生新生儿宫内感染的机会。Objective To research the blocking effect of cesarean section on the mother-to-child hepatitis B virus （HBV） transmission. Method 174 pregnant women were selected as the subjects investigated, who were hepatitis B virus carriers and also they had normal liver function. The pregnant women were given the conventional prenatal （ gestation on 7th, 8th or 9th month, ） injection for 200 IU of Human Hepatitis B Immunoglobulin for three times. The blood from the vein of pregnant women and neonatal umbilici, HBVM and HBV-DNA from the venous blood were tested respectively, the analytical control were performed according to different delivery modes. Results It was double positive hand also for the newborns who were born from the vaginal delivery of the pregnant women with HBV-DNA （ ＋ ）, it was 41.67% for the double positive rate of HBV-DNA （ ＋ ） and the newborns who were born from the cesarean section was 6.67% for the newbores who were born from the cesarean section. There was significant difference on comparing two groups （ P 〈 0. 05 ）. It was double positive and also for the newborns who were born from the vaginal delivery of the pregnant women with HBV- DNA （ - ）, it was 5.88% for the double positive rate of HBV-DNA （ ＋ ） and the newborns who were born from the cesarean section was 7. 69% for the newborns who were born from the cesarean section. The.re was no significant difference on comparing two groups （ P 〉 0. 05）. Conclusion The cesarean section can reduce HBV double positive carrying ratios and the opportunity of intrauterine infection for the newborns that were born by the pregnant women with HBV-DNA-positive.

关 键 词：分娩方式 乙型肝炎病毒 母婴传播 

分 类 号：R719.8[医药卫生—妇产科学]