NK细胞免疫识别及其调节机制与免疫相关性疾病  

Innate recognition and immune regulation of NK cells in immune-related diseases

作　　者：田志刚[1] 魏海明[1] 孙汭[1] 

机构地区：[1]中国科学技术大学生命科学学院免疫学研究所,安徽合肥230027

出　　处：《中国科学技术大学学报》2008年第8期896-904,共9页JUSTC

基　　金：国家重点基础研究发展(973)计划(2007CB512405;2007CB512807;2006CB504300;2004CB518807);国家自然科学基金(30721002;30730084;30630059;30671901;30570819)资助

摘　　要：自然杀伤受体(NKR)和Toll样受体(TLR)是天然免疫系统最重要的二群天然免疫识别受体家族,位于机体抵抗外来侵袭的第一道防线.二者各自具有独特的识别外来或内源性的危险信号、区分自我和非我的识别机制,是启动固有免疫和适应性免疫应答的关键链接分子.NK细胞是天然免疫系统的核心成员,具有早期识别和清除病毒感染和肿瘤细胞等功能,同时也是连接天然免疫和获得性免疫的桥梁.以NK细胞为载体将TLRs/NKRs连接起来,可以较好地反映机体内外环境变化或刺激时固有免疫对适应性免疫的调节作用,为有效控制感染、炎症、肿瘤及自身免疫性疾病提供崭新的治疗策略.Natural killer receptors （NKRs） and Toll-like receptors （TLRs） are the most important receptor supfamilies in innate immunity and act as first line of host defense against infection or transformed cells. These receptors exert peculiar recognition mechanisms to sense danger signals and distinguish infectious nonself from noninfectious self, and thereafter work as link molecules between innate and adaptive immunity. NK cells are the most important lymphocytes population, recognize infection and tumor at initial, and play a critical role in linking innate immunity with adaptive immunity. In this paper, we highlight the importance of recognition and interaction of those receptors via NK cells. The precise mechanisms can be harnessed to aid the rational design of therapy against infection, inflammation, cancer or autoimmune diseases.

关 键 词：NKR TLR NK细胞 天然免疫 免疫调节 

分 类 号：Q257[生物学—细胞生物学] TP18[自动化与计算机技术—控制理论与控制工程]