云克与钙剂、维生素D_3联合治疗原发性骨质疏松症的探讨  

Combination therapy of Yunke,calcium and vitamin D_3 on primary osteoporosis

作　　者：林勇[1] 王雄[1] 肖石[1] 

机构地区：[1]成都铁路中心医院,四川成都610081

出　　处：《四川医学》2008年第9期1183-1185,共3页Sichuan Medical Journal

摘　　要：目的探讨云克与钙剂、维生素联合治疗原发性骨质疏松症的临床疗效。方法选择70例经双能量X线骨密度仪(DEXA)检查证实存在原发性骨质疏松症的患者,其骨密度值(BMD值)<峰值2SD,随机分为治疗组和对照组,治疗组(云克组)35例,治疗方案采用云克5.5mg缓慢静脉推注,1次/d,20d。间隔1周后开始下一疗程。共4个疗程。同时口服钙尔奇D(成分:碳酸钙1.5g,可提供元素钙600mg,维生素D3125IU),1片/d,持续应用半年。对照组35例,应用钙尔奇D,1片/d。治疗前和治疗后6个月分别测定尺桡骨值及BGP、PYD检测。结果用药6个月后治疗组患尺桡骨BMD均有明显增加。结论云克与钙剂、维生素D3联合治疗半年以上可以提高骨质疏松患者质量,从而降低骨折危险度。Objective To explore the clinical effect of combinaton therapy of Yunke（ 99 technetium methylenediphosphonate,99 Tc-MDP） ,calcium and vitamin D3 on primary osteoporosis.Methods Seventy patients suffered from primary osteoporosis with bone mineral density（ BMD）2SD lower than peak value measured by dual-energy X-ray absorptiometry were randomized into treatment group and control group. Treatment group contained 35 cases were treated with treatment protocols included Yunke （5.5mg of Yunke was injected slowly through vein everyday for twenty times and subsequently with an intermission for one week, repeated four times ）, calcium carbonate （1.5g, once daily） and vitamin D3 （125u, once dally）for six month. Control group contained 35 cases were treated with calcium carbonate （ 1.5g,.once daily）and vitamin D3（ 125u, once daily ） for six month. The ulna and radius B MD, serum bone gla protein and urine pyridinoline between the two groups were compared. Results The ulna and radius BMD of treatment group was improved significantly after six month of combination therapy of Yunke, calcium and vitamin D3 . Conclusion Six month of combination therapy of Yunke, calcium and vitain D3 can.improve the BMD and lower the risk of puncture of patients with primary osteoporosis.

关 键 词：^99锝-亚甲基二膦酸盐 钙 维生素D3 骨质疏松 治疗 

分 类 号：R580[医药卫生—内分泌]