腹部肥胖同骨密度、骨矿量的相关性研究  

Relationship between Bone Mass (BMC and BMD) and Obesity in Chinese Hans

作　　者：蒋晓燕[1] 陈艳[2] 许俐[2] 王笑峰[3] 

机构地区：[1]同济大学医学院基础医学院药理教研室,上海市200092 [2]济南市妇幼保健院妇科内分泌,山东济南市250001 [3]复旦大学遗传学研究所,上海市200433

出　　处：《中国康复理论与实践》2008年第9期849-850,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：同济大学07年青年优秀人才基金(No.2007KJ065);山东省济南市卫生局资助项目(No.2007-58)

摘　　要：目的探讨腹部肥胖同骨密度、骨矿量的关系。方法对265例汉族健康志愿者测量腰围及全身各个部位的骨密度及骨矿量。将男性腰围≥85 cm及女性腰围≥80 cm定义为腹部肥胖组;将男性腰围<85 cm及女性腰围<80 cm定义为对照组。腰围值与全身各个部位的骨密度(BMD)骨矿量(BMC)关系进行偏相关分析;腹部肥胖组与对照组组间骨密度及骨矿量比较用协方差分析。结果偏相关分析显示腰围同全身总骨密度(r=0.296),上肢(r=0.254)、下肢(r=0.306)、躯干(r=0.340)、肋骨r=0.368)、骨盆(r=0.381)、脊柱(r=0.260)骨密度,全身总骨矿量(r=0.337),头骨(r=0.169)、上肢(r=0.268)、下肢(r=0.391)、躯干(r=0.327)、肋骨(r=0.358)、骨盆(r=0.302)、脊柱矿量(r=0.269)在消除性别和年龄的影响后均显著正相关(均P<0.01)。协方差分析显示,在消除了性别和年龄的影响后,腰围定义的肥胖同全身、下肢、躯干、肋骨、骨盆、脊柱的骨密度及骨矿量均显著正相关。结论腹部肥胖是骨密度及骨矿量增加的保护因素。Objective To investigate the relationship between bone mass （bone mass content, BMC; bone mass density, BMD） and waistline （WL） related obesity in Chinese Hans lives in Jinan. Methods 265 consecutively healthy volunteers were recruited in Jinan. BMC and BMD of all subjects were measured with dual energy X-ray absorptiometry. Obesity was defined as a WL ≥85 cm in men or ≥80 cm in women. Analysis of covariance （ACNOVA） and partial correlation were used. Results Partial analysis showed that there is a linearity positive correlation between bone mass and WL. After controlling for gender and age, correlation coefficients of WL with BMD in all over the body, extremities inferior, pars trunk, cervical rib, basin and backbone of Pearson were 0. 296, 0. 306, 0. 340, 0. 368, 0. 381 and 0. 260 （P=0. 000）. Correlation coefficients of WL with BMC in all over the body, extremities in ferior,pars trunk, cervical rib, basin and backbone were 0. 337,0. 391, 0. 327, 0. 358, 0. 302 and 0. 269 （P=0. 000）. ACNOVA showed that there is a significant difference of bone mass between obesity and non-obesity subjects after adjusted for age and gender. Conclusion There is a positive correlation between obesity and bone mass in Chinese Hans.

关 键 词：肥胖 腰围 骨密度(BMD) 骨矿量(BMC) 

分 类 号：R681[医药卫生—骨科学]