肺心病患者肾上腺髓质素、降钙素基因相关肽和C型利钠肽监测的临床研究  

Clinical Monitoring of Adrenomedullin,Ccalcitonin Gene-related Peptide and C-type Natriuretic Peptide in Patients with Pulmonary Heart Disease

作　　者：黄金龙[1] 

机构地区：[1]昆明医学院第四附属医院,云南昆明650032

出　　处：《昆明医学院学报》2008年第4期123-126,共4页Journal of Kunming Medical College

摘　　要：目的探讨肺源性心脏病患者体内肾上腺髓质素(ADM)、降钙素基因相关肽(CGRP)和C型利钠肽(CNP)的变化规律.方法应用放射免疫分析的方法,检测临床确诊的60例肺心病急性发作期患者治疗前后和60例健康体检者,血浆中ADM、CGRP、CNP的水平并进行比较.结果治疗前ADM、CGRP、CNP的水平较健康体检组明显升高(P<0.01),治疗后较治疗前降低,差异有统计学意义(P<0.01).并且ADM、CGRP、CNP与PaO2呈负相关(r=-0.52,P<0.01),与PaCO2无相关关系(r=0.20,P>0.05).结论通过对肺心病患者血浆中ADM、CRGP、CNP的测定为肺心病的防治研究提供新的观察指标.Objective To investigate the pattern of adrenomedullin （ADM） , calcitonin gene-related peptide （CGRP） , C-type natriuretie peptide （CNP） in the patient with pulmonary heart disease. Method To detect plasma ADM, CGRP, CNP in 60 cases of acute pulmonary heart disease patients before and after treatmen and 60 cases of healthy people using radioimmunoassay, and compare them. Results ADM, CGRP, CNP is signifieent higher than the healthy people （P 〈0.01） , ADM, CGRP, CNP is reduced significantly after treatment （P〈 0.01 ）. And ADM, CGRP, CNP was negatively correlated with PaO2 （r= - 0.52, P〈 0.01）, but have no correlation with PaCO2（r = 0.20, P〉 0.05）. Conclusion The detection of ADM, CRGP, CNP in the blood plasma can offer new standard for the prevention and euration of pulmonary heart disease.

关 键 词：肺心病 ADM CGRP CNP 放免测定 

分 类 号：R541.5[医药卫生—心血管疾病]