前列腺增生MR波谱分析与病理大切片对照研究  

Study on correlation between MR spectroscopy and whole pathologic section in benign prostatic hyperlPlasia

作　　者：史志杰[1] 李峰[2] 王守红[3] 王霄英[4] 赵丽君[3] 李晓强[2] 

机构地区：[1]唐山工人医院分院泌尿外科,063000 [2]华北煤炭医学院附属医院泌尿外科 [3]开滦医院MR室 [4]北京大学第一医院医学影像科

出　　处：《中华放射学杂志》2008年第9期954-956,共3页Chinese Journal of Radiology

摘　　要：目的探讨前列腺增生不同组织类型在MR波谱（MRS）检查中的代谢差异、临床应用价值及尿道周围单体MRS代谢特点。方法对16例前列腺增生患者术前行MRS检查，并测定（胆碱＋肌酸）／枸橼酸盐（cc／c）值。行耻骨上经膀胱前列腺摘除术，术后标本行病理大切片检查，采用一一对应的方法，将波谱图像cc／c值与前列腺组织病理类型（包括尿道）分别记录后，采用One—way-ANOVA检验和t检验进行不同组织类型间的比较。结果前列腺的腺体型组织、间质型组织、混合型组织和尿道周围单体分别为233、130、165和50个，其cc／c值分别为0．59±0．29、1．23±0．38、0．80±0．27和0．68±0．33，差异有统计学意义（F=3．49，P〈0．05）。其中腺体型组织与间质型、混合型组织比较，间质型组织与混合型组织、尿道周围组织比较，混合型组织与尿道周围组织比较，差异均有统计学意义（t值分别为19．60、7．09、13．22、9．42和9．42，P值均〈0．05）。结论前列腺增生不同组织类型在MRS分析检查中的cc／c值存在差异，尿道周围单体MRS代谢特点与腺体型组织相近，此方法可能对确定诊断阈值有一定意义。Objective To investigate the metabolic characteristics, clinic values of different tissues in benign prostatic hyperplasia by correlating MR spectroscopy （MRS）with whole pathologic sections. Methods MRS presentation was studied in 16 patients with benign prostatic hyperplasia. The peak values of citrate, choline and creatine were measured, and the ratios of （choline ＋ creatine）/citrate （cc/c） were obtained. After suprapubic transvesical prostatectomy, the specimens of whole pathologic sections were observed. The values of cc/c of different pathologic types were compared statistically with One-way-ANOVA and t test. Results MRS results were obtained in 578 units, which included 233 glandular tissue units, 130 matrical tissue units, 165 mixed tissue units and 50 tissue units around urethra. The ratios of （choline ＋ creatine）/citrate of glandular, matrical, mixed tissues and units around urethra were 0. 59 ± 0.29, 1.23±0.38,0.80±0.27 and 0.68 ±0.33（F=3.49,P〈0.05）. The t tests were carried out between every two tissues. The t values between glandular tissues and matrical, mixed tissues were 19.60 and 7.09,P 〈 0. 05; the t values between matrical tissues and mixed tissues, units around urethra were 13.22 and 9.42, P 〈 0. 05 ; the t values between mixed tissues and units around urethra was 9.42, P 〈 0. 05. Conclusions The ratios of cc/c of three prostate tissues were different in MRS. The metabolic characteristic of the units around urethra was near to glandular units. MRS may be valuable to the distinctive diagnoses of prostate diseases.

关 键 词：前列腺增生 磁共振波谱学 对比分析 

分 类 号：R686[医药卫生—骨科学]