冠心病证候要素组合与心功能及血脂的相关性  

Correlation between syndrome factor combination and cardiac function as well as blood-lipid in coronary heart disease

作　　者：王阶[1] 何庆勇[1] 施展[1] 邢雁伟[1] 李霁[1] 房玉涛[1] 汤艳莉[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中西医结合学报》2008年第9期897-901,共5页Journal of Chinese Integrative Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(No2003CB517103);国家自然科学基金重大计划面上项目(No90209011);中国中医科学院中医治疗有特色和优势病种项目(NoCACMS05Y0010)

摘　　要：目的:探讨冠心病证候要素及组合的分布规律,并分析其与心功能及血脂水平的相关性。方法:采用超声心动图测定300例经冠状动脉造影术确诊的冠心病患者的心功能指标并检测其血脂水平,分析冠心病证候要素组合与心功能及血脂水平的相关性。结果:冠心病证候要素主要组合有气虚血瘀、气阴两虚、痰瘀互阻和阳虚血瘀。阳虚血瘀型冠心病患者射血分数显著降低,气阴两虚和痰瘀互阻型冠心病患者甘油三酯水平显著升高,痰瘀互阻型冠心病患者的低密度脂蛋白胆固醇显著升高。结论:冠心病的治疗应标本兼顾,以益气活血、养阴化痰、通阳宣痹的方药为主。心功能差的冠心病患者在治疗上应侧重运用通阳活血的方药,合并血脂异常的患者在治疗上应侧重运用活血化痰或益气养阴的方药。Objective： To discuss the distribution laws of traditional Chinese medicine （TCM） syndrome factor and their combination in coronary heart disease （CHD）, and to study the correlation between the TCM syndrome factor combination and cardiac function as well as blood-lipid. Methods： The parameters of the cardiac function of 300 patients with a final diagnosis of CHD by coronary angiography were measured by echocardiography, and the levels of blood lipids in the CHD patients were detected. An analysis of the correlation was done between the TCM syndrome factor combination and cardiac function as well as blood-lipid in CHD. Results： The TCM syndrome factor combinations of CHD were blood stasis due to qi deficiency, qi and yin deficiency, intermingled phlegm and blood stasis, and yang deficiency and blood stasis. The ejection fraction of CHD patients with yang deficiency and blood stasis was markedly decreased. The levels of triglyceride and low-density lipoprotein cholesterol in CHD patients with intermingled phlegm and blood stasis were markedly increased, and the level of triglyceride in CHD patients with qi and yin deficiency was markedly increased too. Conclusion： The treatment of CHD should aim directly at the symptoms and causes. It is also proved that some compound traditional Chinese herbal medicines for supplementing qi and activating blood circulation, nourishing yin and resolving phlegm, and activating yang should be used in treatment of CHD. In cases of CHD with low cardiac function, particular emphasis should be laid on activating yang and blood circulation, while in cases of CHD with blood-lipid disturbance, particular emphasis should be laid on resolving phlegm and activating blood circulation, replenishing qi and nourishing yin.

关 键 词：冠状动脉心脏病 动脉造影术 证候 

分 类 号：R541.4[医药卫生—心血管疾病]