KLOTHO基因C-1818T多态性与中国苏皖地区汉族人群急性冠脉综合征易感性的关系  

Association of KLOTHO gene C-1818T polymorphism with acute coronary syndrome in the Chinese Han population of Suwan region

作　　者：何国平[1] 金鸣锋[1] 杨进[2] 王俊宏[2] 戚传平[1] 高磊[1] 沈丽娟[1] 杨国英[1] 杨笛[2] 张寄南[2] 

机构地区：[1]常州市武进人民医院,江苏213002 [2]江苏省人民医院心血管病研究所,江苏210000

出　　处：《常州实用医学》2008年第4期211-216,共6页CHANGZHOU PRACTICAL MEDICINE

摘　　要：目的 探讨KLOTHO基因第四外显子C-1818T多态性与中国苏皖地区汉族人群急性冠脉综合征（acute coronary syndrome，ACS）的可能关系。方法应用聚合酶链反应（polymerase chain reaction，PCR）及基因芯片（gene microarray）技术对375例ACS患者（ACS组）和235例经相关检查排除冠心病（CAD）者（对照组）进行KLOTHO基因C-1818T多态性的检测。结果与对照组相比：（1）ACS患者CC、CT和TT基因型以及T等位基因型频率分布无显著差异；（2）老年人（≥60岁）、男性和老年男性ACS患者的CT基因型频率均明显升高（P值分别为0．031、0．035和0．041）。在调整相关危险因素并经多元Logistic回归分析后，CT基因型与老年人和老年男性ACS均存在相关关系（P值分别为0．010和0．047），与男性ACS无明显相关关系（P=0．103）。结论在中国苏皖地区汉族人群中，KLOTHO基因C-1818T多态性CT基因型与老年和老年男性ACS的发病均存在相关性。Objective To investigate the possible association between the C - 1818T polymorphism in exon 4 of KLOTHO gene and acute coronary syndrome（ACS）in the Chinese Han population of Suwan region. Methods This study was conducted with a ease - control design including 375 patients with ACS（ ACS group） and 235 control subjects who were free from coronary artery disease by coherence cheeks（control group） . The KLOTHO gene C - 1818T polymorphism was determined by polymerase chain reaction（ PCR） and gene mieroarray. Results Compaired with the control group, （1） The frequencies of CC. CT、IT genotype and the T allele of the C- 1818T in ACS group was not significantly different; （2）The prevalence of the CT genetype is obveriously higher in elderly pafients（age≥60 years）,male and also the elderly male with ACS（P value was 0.031,0.035,0.041 respectively）. Furthermore, after adjustment for conventional risk factors by multiple logistic regression analysis, It was showed that the CT genotype was a significant risk factor for ACS in the elderly or elderly male earrier（P value was 0.010 and 0.047 respectively） and no association with ACS in male（ P = 0.103）. Conclusion The CT genetype of KLOTHO gene C - 1818T polymorphism was associated with the susceptibility to ACS in the eldedy（age≥60 years）, especially in elderly male in the Chinese Han population of Suwan region.

关 键 词：KLOTHO 基因多态性 急性冠脉综合征 

分 类 号：R339.38[医药卫生—人体生理学] R541.4[医药卫生—基础医学]