KLOTHO基因启动子G-395A多态性与急性冠脉综合征的相关性分析  

Association of KLOTHO gene promoter G- 395A polymorphism with acute coronary syndrome

作　　者：何国平[1] 金鸣锋[1] 高磊[1] 杨进[2] 王俊宏[2] 沈丽娟[1] 杨笛[2] 张寄南[2] 

机构地区：[1]常州市武进人民医院,江苏213002 [2]江苏省人民医院心血管病研究所,江苏210000

出　　处：《常州实用医学》2008年第3期145-150,共6页CHANGZHOU PRACTICAL MEDICINE

摘　　要：目的探讨KLOTHO基因启动子G-395A多态性与中国苏皖地区汉族人群急性冠脉综合征（acute coronary syndrome，ACS）的关系。方法采用聚合酶链反应（PCR）和基因芯片（gene microarray）技术对326例ACS（ACS组）[分为亚组急性心肌梗死（acute myocardial infarction，AMD组和不稳定性心绞痛（unstable angina pectoris，UAP）组]和219例经相关检查排除冠心病（CAD）的对照组进行KIDTHO基因G-395A多态性检测。结果与对照组相比，ACS组、AMI组和UAP组（包括不同年龄和不同性别的亚组）的GG、GA、从基因型和A等位基因频率均无明显差异（P均〉0．05）。结论K101HO基因G-395A多态性与ACS的发病无显著相关性。Objective To investigate the possible association between the KLOTHO gene G- 395A polymorphism in promoter and acute coronary syndrome（ACS）in the Chinese Hart population of Suwan region. Methods This study was conducted with a case- control design including ACS group which is consisted of 326 patients with ACS [acute myocardial infaretion（AMI） group and unstable angina pectoris（UAP）group] and 219 control subjects（control group）who were free from coronary artery disease by coherence checks.The KLOTHO gene G- 395A polymorphism was determined by polymerase chain reaction（PCR） and gene microarray. Results Compaired with the control group, the prevalence of G - 395A polymorphism and the A allele were not significantly different in ACS、AMI、UAP groups and the subjects subgrouped according to sex and age（ P 〉 0.05）. Conclusion Our findings suggest that the G - 395A polymorphism in KLOTHO gene may be not the risk for ACS in the Chinese Han population of Suwan region.

关 键 词：KLOTHO 基因多态性 急性冠脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病] R737.250.2[医药卫生—内科学]