多孔钛免疫隔离技术  

Feasibility of Immunoisolation Based on Porous Titanium

作　　者：詹敏晶[1] 李刚[1] 魏强[2] 崔华雷[1] 林凌[1] 

机构地区：[1]天津大学精密仪器与光电子工程学院,天津300072 [2]天津大学材料科学与工程学院,天津300072

出　　处：《纳米技术与精密工程》2008年第5期327-330,共4页Nanotechnology and Precision Engineering

摘　　要：为了克服基于高分子材料的免疫隔离膜的吸水膨胀、机械强度差等缺点,提出将多孔钛用于免疫隔离技术.采用粉末冶金的方法制备多孔钛,将400目钛粉按所需质量于320MPa压力下挤压成型后,在氩气的保护下进行烧结,于980℃保温4h.烧结出的多孔钛孔径小于3μm,孔隙率达35.6%.压缩实验表明,膜厚200μm的多孔钛片能承受2kN以上的压缩力.由免疫隔离实验与物质通透性实验可知,多孔钛免疫隔离膜具有选择透过性,即小于葡萄糖、氨基酸分子量的小分子营养物质或代谢产物能自由进出多孔钛膜,同时阻碍免疫细胞(如自然杀伤细胞)自由进出该膜.实验结果说明多孔钛金属能应用于免疫隔离技术.Porous titanium is used as a new method on immunoisolation in order to overcome defects of immunoisolation membrane based on polymer such as water swelling and low mechanical strength. The feasibility was studied on the immunoisolation based on porous titanium through permeable experiments, immunoisolation experiments, etc. Porous titanium was prepared by the powder metallurgy. Raw powders of 400 mesh were pressed at 320 MPa with the desired weight. And then sintered process was performed by argon protection under 980℃ for 4 hours. The aperture sizes of sintered porous titanium are less than 3μm and its porosity is about 35.6%. The experiment results show that porous titanium with the thickness of membrane of about 200μm can withstand above the pressure of 2 kN. Porous titanium membranes possess selectively permeability, i.e. the immunocyte, such as natural killer（NK） ceils can be hindered the passage by the kind of membranes, at the same times, small molecules can relatively freely pass the membranes, for example, geglucose and amino acid. The experiment results proved that porous titanium can be used as semipermeable membrane for immunoisolation.

关 键 词：多孔钛 免疫隔离 粉末冶金 细胞移植 

分 类 号：TB383.4[一般工业技术—材料科学与工程]