聚乳酸头孢唑啉钠微球的制备及其释药性能  

Preparation and Drug-releasing Performance Research of Polylactic Acid-cefazolin Sodium Microspheres

作　　者：冯晓健[1] 王伟 赵敏[1] 

机构地区：[1]南京师范大学化学与环境科学学院

出　　处：《南京师大学报（自然科学版）》2008年第3期76-80,共5页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：南京大学固体微结构物理国家重点实验室基金(M05010)资助项目

摘　　要：采用复乳法制备了聚乳酸—头孢唑啉钠(PLA-CEZ)微球.扫描电子显微镜(SEM)、差热分析(DTA)和红外光谱(FT-IR)的实验结果表明,PLA-CEZ呈现完整的球形且聚乳酸和模型药物能够有机地结合为一体.同时,探讨了聚乳酸分子量大小及释药介质对载药微球释放速率的影响.The PLA-CEZ microspheres were prepared successfully by the double emulsion method and were characterized by scanning electron microscope （SEM） , differential thermal analysis （DTA） and IR spectroscopy. The results demonstrated that the PLA-CEZ microspheres were spherical and polylactic acid mingled together with cefazolin sodium. The effects of molecular weight of PLA and medium on the drug-releasing performance of the PLA microspheres were also investigated.

关 键 词：复乳法 药物缓释 聚乳酸 头孢唑啉钠 微球 

分 类 号：R318.08[医药卫生—生物医学工程]