胆乐化瘀片防止食饵性胆固醇结石的实验研究  

Experimental Research of Prevention of Eating Bait Cholesterol Stone with Danlehuayu Tablets

作　　者：吕锋 李中明 宁立芬 

机构地区：[1]武汉科枝大学附属汉阳医院,湖北武汉430050

出　　处：《湖北中医学院学报》2008年第3期14-15,共2页Journal of Hubei College of Traditional Chinese Medicine

摘　　要：目的探讨胆乐化瘀片防止食饵性胆固醇结石机理。方法通过改变饮食成分诱发豚鼠胆结石。各组连续喂养8周后(各给药组拌入规定剂量的药物),观察肝脏的病理变化,从胆囊中收集胆石,吸取胆囊胆汁,测定胆汁中成分的含量。结果胆乐化瘀片预防组的成石率均显著降低,其高剂量预防组成石率降至0%。模型组动物肝脏发生明显脂肪变性,其发生率为90%;而预防组动物发生率仅为40%(低剂量组)和20%(高剂量组)。结论胆乐化瘀片通过调节胆汁酸的代谢,增加胆汁酸的含量;降低胆汁中游离胆红素的含量;以及利胆等综合作用与防止胆石的形成有关。Objective： Study the mechanism on prevention of eating bait cholesterol stone with Danlehuayu tablets. Method ： Change dietetic component to induce gall - stone in cavies and feed every group continuously for 8 weeks （ every group is given the same dose of drugs）. Then observe the pathologic change of the liver; bring out all the gallstones. And collect the bile in the liver to determine the content of its components. Results ： The rate of gallstone formation of the groups using Danlehuayu tablets all reduce prominently. Moreover, the high dose reduce to 0%. The livers of the model groups all had evident fat denaturalization, and the rate is 90%. While, the rate of the using medicine groups is only 40% （ low dose group） and 20% （ high dose group）. Conclusion ： Danlehuayu tablets have sever pharmacological effects： （ 1 ） increasing the content of bile acid through adjusting its metabolism; （2） reducing the content of the dissociative bilirubin in bile; （3） draining gallbladder; etc. These effects are related to the prevention gallstone formation.

关 键 词：胆乐化瘀片 胆固醇结石 胆石症 预防 利胆 

分 类 号：R285.5[医药卫生—中药学]