香豆素类化合物抗肿瘤作用研究进展  

Research progress on effect of coumarins compounds in anti-tumor

作　　者：郝光[1] 王振国[1] 付文艳[1] 杨英[1] 

机构地区：[1]内蒙古农业大学动物科学与医学学院,内蒙古呼和浩特010018

出　　处：《中国中药杂志》2008年第18期2016-2019,共4页China Journal of Chinese Materia Medica

摘　　要：香豆素(coumarin)是一类具有苯并α吡喃酮母核天然产物的总称,通常依据α吡喃酮环上取代基的不同结合,将其分为简单、呋喃、吡喃和其他香豆素类化合物4种。实验研究发现香豆素类化合物具有抗HIV、抗癌、降压、抗心律失常、抗骨质疏松、镇痛、平喘及抗菌等多种生物活性,具有潜在的药用价值,其中抗肿瘤作用是一个研究热点。因此,研究开发更多天然植物香豆素成分,寻找有效的先导化合物,完善香豆素类化合物的提取工艺,合成并筛选出高效低毒的香豆素类化合物及其衍生物已成为当今药物研究与开发工作的重中之重。Coumarins are a group of important natural compounds, and have been found to have multi-biological activities such as anti-HIV, anti-tumor, anti-hypertension, anti-arrhythmia, anti-osteoporosis, assuaging pain, preventing asthma and antisepsis. One of which is its anti-tumor effect and that is a research focus on. Therefore, we believe that it is necessaryto carry out further studies on the effect of coumarins compounds in anti-tumor. Investigation should emphasize on improving techniques for extraction and separation, searching the effective precursory compound, and synthesizing and screening out courmarin derivatives with high activity and low toxicity. Here the recent research progress in anti-tumor effect of coumarins compounds is reviewed.

关 键 词：香豆素 抗肿瘤 综述 

分 类 号：R285.5[医药卫生—中药学]