苦参碱对高脂肥胖大鼠体重、血脂和过氧化能力的影响  

Effects of Matrine on Weight,Serum Lipids and Anti-oxidative Capacity in High-fatted Rats

作　　者：袁良杰[1] 卢霞[1] 王君[1] 郑天珍[1] 瞿颂义[1] 张小郁[1] 

机构地区：[1]兰州大学基础医学院生理与心理研究所,甘肃兰州730000

出　　处：《时珍国医国药》2008年第9期2062-2064,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金资助项目(No.30572428)

摘　　要：目的观察苦参碱对高脂性肥胖大鼠体重、血脂和抗氧化能力的影响,并初步探讨其作用机制。方法将44只雄性SD大鼠随机分为对照组、高脂组、苦参碱低剂量组(7.5 mg.kg-1.d-1)、中剂量组(15 mg.kg-1.d-1)和高剂量组(30mg.kg-1.d-1)。每天定时灌胃,记录进食量,每周定时称体重。8周末采血,测血糖和血清生化指标,观察苦参碱对大鼠体重、脂类代谢和抗脂质过氧化作用等的影响。结果与高脂组比较,苦参碱高、中和低剂量组均可以明显降低肥胖大鼠的热量摄入和体重。与高脂组比较,苦参碱中剂量组血糖、甘油三酯、游离脂肪酸、丙二醛和谷丙转氨酶的含量均有明显的降低,而总抗氧化能力提高。结论苦参碱可明显抑制高脂性肥胖大鼠体重的增加,调节糖脂代谢紊乱,增强抗脂质过氧化能力,保护肝脏功能。Objective To observe the effects of matrine on weight, serum lipids and anti - oxidative capacity in high-fatted SD rats. Methods Fouty - four SD rats were randomly divided into five groups： control group, high - lipid group , high-dose matrine group（30 mg · kg^-1· d^-1）, middle-dose matrine group（ 15 mg · kg^-1· d^-1） and low-dose matrine group（7.5 mg· kg^-1· d^-1）. SD rats were fed with ordinary diet and administered physiological saline in control group and high - lipid group and other SD rats were administered matrine and fed with high - fat diet. Food intake was monitored daily, and body weight was weighed weekly at set time . At the end of the eighth week, blood glucose and serum biochemical indexes were determined. Resuits Matrine significantly reduced the body weight （P 〈 0.05 ）. Middle - dose matrine decreased blood glucose, the fasting serum levels of malondialdehyde, free fatty acids, glutamic - pyruvic transaminase and elevated the total antioxidative capacity. Conclusion Matrine can significantly inhibit the weight gain of high - fatted rats, regulate the blood lipids and blood glucose metabolism disorders, enhance anti -lipid peroxidation and protect the liver function.

关 键 词：苦参碱 高脂肥胖 体重 丙二醛 

分 类 号：R285.5[医药卫生—中药学]