金刚纂化学成分研究  

Studies on the chemical constituents of Euphorbia antiquorum L.

作　　者：李芸芳[1] 田学军[1] 杨光忠[1] 陈玉[2] 

机构地区：[1]中南民族大学生命科学学院,武汉430074 [2]中南民族大学化学与材料学院,武汉430074

出　　处：《华中师范大学学报（自然科学版）》2008年第3期396-399,共4页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金项目(30670215)

摘　　要：利用系统溶剂提取法、正相和反相硅胶柱色谱法等手段,从金刚纂70%乙醇提取物中分离得到6个化合物.化合物经波谱分析鉴定为3,3’,4-’tri-O-methylellagic acid(1),3,3-’di-O-methylellagic acid(2),6,7,8-trimethoxy-coumarin(3),7-hydroxy-6-methoxy-coumarin(4),Kaempferol-3-O-a-L-rhamnopyranoside(5),胡萝卜苷(6).其中,化合物2,4,5为首次从该植物中分离得到.并对其中的两个香豆素化合物3和4的光活化抗微生物活性进行了研究.结果显示,化合物3和4在黑暗中和紫外光的照射后,对金黄色葡萄球菌和枯草芽胞杆菌未表现出抗菌活性.To study the chemical constituents of Euphorbia antiquorum L. , the air-dried stems of this plant were extracted with 70% ethanol. The extracts were purified by normal-phase and reverse phase silica gel column chromatography. Six compounds were obtained from Euphorbia antiquorum L. They were identified as to be 3,3＇, 4 ＇-tri-O-methylellagic acid （1）, 3,3 ＇-di-O-methylellagic acid （2）, 6,7,8-trimethoxyl-coumarin （3）, 7-hydroxy-6-methoxy-coumarin （4）, Kaempferol-3-O-α-L-rhamnopy ranoside （5）, daucosterol （6） by spectral analysis. Among them, compounds 2, 4 and 5 were isolated from this plant for the first time. Compounds 3 and 4 were screened for their photoactivated antimicrobial activities against 2 bacterial strains, Staphylococcus aureus and Bacillus subtilis by TLC bioautography technique, but none of them displayed antibacterial activities in the dark and UV.

关 键 词：大戟属 金刚纂 化学成分 

分 类 号：O629[理学—有机化学]