大鼠静脉注射3种铂制剂后铂的肾排泄与肾分布比较研究  

Renal Excretion and Distribution of Platinum of 3 Kinds of Platinum Preparation in Rats:A Comparative Study

作　　者：李秀琴[1] 陈西敬[2] 任伟超[2] 张辉[2] 顾萱[2] 

机构地区：[1]青海卫生职业技术学院药理教研室,西宁市810000 [2]中国药科大学,南京市210009

出　　处：《中国药房》2008年第28期2187-2188,共2页China Pharmacy

摘　　要：目的:探讨铂类抗癌药的肾毒性机制。方法:12只大鼠均分为3组,分别按铂元素10mg·kg-1剂量静脉注射顺铂、卡铂和双环铂,采用原子吸收法测定并计算4h尿药累积排泄率及肾组织中浓度。结果:4h累积排泄率顺铂、卡铂、双环铂分别平均为(33.7±5.7)%、(89.1±8.5)%、(70.1±9.8)%,肾组织中铂的浓度分别为(70.6±31.6)、(217.7±97.6)、(278.8±112.0)μg.g-1。结论:与顺铂相比,双环铂与卡铂肾排泄较快,肾组织中的铂浓度相对较高;肾组织中铂浓度高低与肾毒性大小之间可能无直接关系。OBJECTIVE： To study the mechanism of renal toxicity of platinums in rats. METHODS： A total of 12 rats were equally assigned to receive cisplatin, carboplatin, or dicycloplatin i.v with the dosage of platinum at 10 mg · kg ^-1. The cumulative excretion rate of platinum in urine in 4 h and the concentration of platinum in renal tissue were measured by atom absorption method. RESULTS： The total excretion percent of platinum in urine in the first 4 h after injection of cisplatin, carboplatin, and dieycloplatin were （33.7±5.7） %, （89.1±8.5） % and （70.1±9.8） % respectively. The renal platinum concentration were 70.6± 31.6, 217.7± 97.6, and （278.8± 112.0） ug · g^-1, respectively. CONCLUSIONS： Both the renal excretion speed and renal concentrations of platinum were higher for dicycloplatin and carboplatin than for cisplatin. The nephrotoxicity of platinum drugs probably has no direct relationship with the renal concentration of platinum.

关 键 词：双环铂 卡铂 顺铂 肾排泄 肾组织 浓度 

分 类 号：R965[医药卫生—药理学] R979.1[医药卫生—药学]