家兔体内思密达对左氧氟沙星药动学的影响  

Effect of Smecta on the Pharmacokinetics of Levofloxacin in Rabbits

作　　者：杨玉芳[1] 李梅[1] 李健[1] 周燕文[1] 

机构地区：[1]广西医科大学第一附属医院,南宁市530021

出　　处：《中国药房》2008年第28期2191-2192,共2页China Pharmacy

摘　　要：目的:探讨口服思密达和左氧氟沙星后左氧氟沙星的药动学有无改变。方法:取家兔6只随机交叉(间隔1周)经口灌胃左氧氟沙星(A组)、左氧氟沙星+思密达(B组)、左氧氟沙星2h后+思密达(C组)。采用高效液相色谱法测定不同时间血样中左氧氟沙星浓度,计算并比较药动学参数。结果:A组与C组比较,Cmax、tmax、AUC、t1/2均无显著性差异(P>0.05);B组除tmax与其它组无差异外(P>0.05),t1/2延长,AUC、Cmax值降低(P<0.05)。结论:同时使用左氧氟沙星和思密达,可明显改变前者的药动学参数;使用左氧氟沙星2h后再用思密达,此用药方案较为合理。OBJECTIVE： To observe the variation of pharmacokinetics after oral administration of smecta and levofloxacin. METHODS： Six normal rabbits were randomly assigned to receive levofloxacin alone （group A）, levofloxacin plus smecta （group B） or smecta 2 hours after oral administration of levofloxacin （group C） in a randomized crossover design （with an interval of 1 weeks） . The concentration of levofloxaein in serum sampled at different time was determined by HPLC, and the pharmacokinetics of levofloxacin was computed and compared. RESULTS： The pharmacokineties （C t AUC, t 1/2） of levofloxacin had no statistical differences between group A and group C （P 〉 0.05） . There was no statistical difference in tmax between group B and the other groups （P 〉0.05）, but the t 1/2 was longer and the AUC and the Cmax were lower in group B than in other groups （P 〈 0.05）. CONCLUSIONS： The pharmacokinetics of levofloxacin can be changed remarkably if it is taken concurrently with smecta. It is reasonable to take smeeta 2 h after oral administration of levofloxaein.

关 键 词：左氧氟沙星 思密达 相互作用 药动学参数 血药浓度 

分 类 号：R969.2[医药卫生—药理学] R975[医药卫生—药学]