无痛流产中丙泊酚芬与太尼应用间隔时间分析  

Analysis of Interval Time between Propofol and Fentanyl in Analgesia Abortion

作　　者：李国先[1] 刘燕[1] 卢晓芬[1] 袁欣[1] 

机构地区：[1]山东省聊城市人民医院妇产科门诊,252000

出　　处：《中华全科医学》2008年第10期1029-1030,共2页Chinese Journal of General Practice

摘　　要：目的观察无痛流产术中丙泊酚与芬太尼不同间隔时间的镇痛效果及并发症。方法选择无痛流产病例1700例,分为观察组(n=900)和对照组(n=800),观察组术中静脉用芬太尼4min后再给丙泊酚,对照组术中用芬太尼后即给丙泊酚,比较2组麻醉镇痛效果、应用剂量及并发症。结果与对照组相比,观察组患者宫缩痛发生率较小(4.11%vs6.38%,χ2=4.42,P<0.05),呼吸抑制率较低(2.22%vs13.62%,χ2=122.47,P<0.01),丙泊酚总量减少(103.70±51.20vs132.3±8.65,t=8.17,P<0.05)及追加剂量减少(19.10±11.30vs27.20±18.60,t=10.69,P<0.05)。结论人工流产术中芬太尼和异丙酚间隔4min使用镇痛效果满意,利于手术操作,未见明显呼吸抑制,值得推广。Objective To observe the analgesic effect and complications of Propofol and Fentanyl at different interval time in analgesia abortion. Methods 1 700 analgesia abortion cases were divided into two groups. Propofol was administered 4 minutes after Fentanyl in the observation group（ n = 900）, and immediately after Fentanyl in the control group（ n = 800）. The dose, analgesia effect and complications were compared between the both groups. Results Compare the observation group with the control group, the pain rate caused by uterine contraction was less （4.11% vs 6.38% , X2 = 4.42,P 〈 0.05 ） , respiratory depression rate was lower（2.22% vs 13.62%, X2 = 122.47, P 〈 0.01 ）, total amount of propofol was little （ 103.70± 51.20 vs 132.3 ± 8.65, t=8.17,P〈0.05） ,and supplemental dose was low （19.10 ±11.30 vs 27.20 ±18.60,t=10.69,P〈0.05）. Conclusions A better analgesia effect can be achieved by Fentanyl and Propofol at a interval time of 4 minutes in the analgesia abortion operations with lower respiratory depression. It is worthy to be generalized in clinic.

关 键 词：丙泊酚 芬太尼 无痛流产 

分 类 号：R169.421[医药卫生—公共卫生与预防医学]