辛伐他汀对中老年慢性肾炎患者尿蛋白及C反应蛋白的影响  

Effects of Simvastatin on Proteinuria and Plasma CRP in the middle-aged patients with chronic nephritis

作　　者：菅宏蕴[1] 周再生[1] 崔惠敏[1] 

机构地区：[1]中山大学附属中山医院肾内科,528403

出　　处：《中国现代药物应用》2008年第19期4-5,共2页Chinese Journal of Modern Drug Application

摘　　要：目的研究辛伐他汀对血脂控制正常的中老年慢性肾炎患者蛋白尿的治疗作用及其与CRP的关系。方法60例血脂控制正常的中老年慢性肾炎患者随机分为他汀组(30例)或对照组(30例),分别给与辛伐他汀(20mg)或安慰剂治疗3个月,观察24h尿蛋白定量,血浆C-反应蛋自(CRP)、血脂(TG、TC、HDL-C、LDL-C)的变化。结果治疗3月后与对照组比较他汀组的24h尿蛋白定量,血浆C-反应蛋自(CRP)),明显低于对照组(P<0.05);TG、TC、HDL-C、LDL-C与对照组比较无统计学意义P>0.05。结论辛伐他汀能减轻中老年慢性肾炎患者尿蛋白排出,该作用可能通过降脂以外的降低炎症因子CRP的抗炎作用实现的。Objective To study the therapeutic effects of Simvastatin on proteinuria, CRP, in the middie-aged Patients with chronic nephritis. Methods Sixty middle-aged patients with chronic nephritis whose Plasma lipids had been well-controlled were randomized to receive Simvastatin （20 mg/d, n-30） or placebo （n- 30） treatment for three months. Plasma C-reactive protein（CRP） ,24 h proteinuria , triglycerides , total cholesterol, HDL cholesterol, LDL cholesterol were measured before and after the study. Results Triglycerides ,total cholesterol, HDL cholesterol, LDL cholesterol of patients between Simvastatin and placebo groups were similar（P 〉 0. 05 ）. After 3 months treatment, CRP proteinuria in Simvastatin group were decreased significantly compared to those in placebo group（P 〈 0.05）. Conclusion In addiction to its antlipidemia effect, Simvastatin was shown to be a beneficial on reduction proteinuria in the middle-aged Patients with chronic nephritis which may be attributed to its antinflammatory effect of lower in plasma CRP levels.

关 键 词：辛伐他汀 慢性肾炎 蛋白尿 C-反应蛋白 

分 类 号：R692.3[医药卫生—泌尿科学]