深圳市居民4123人骨密度分析及骨质疏松患病率调查  

Bone mineral density and osteoporosis prevalence in 4 123 citizens from Shenzhen

作　　者：杨春菊[1] 张鉥缨[1] 吴远[1] 

机构地区：[1]北京大学深圳医院特诊科,广东省深圳市518036

出　　处：《中国组织工程研究与临床康复》2008年第37期7338-7340,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:近年来国内外资料显示骨质疏松患病年龄有年轻化趋势,区域差异较大。目的:调查深圳市正常人群骨密度的变化规律及骨质疏松的患病率。设计、时间及地点:横断面调查,于2003-01/2008-02收集在北京大学深圳医院特诊科体检的深圳市汉族居民4123人的股骨骨密度测量结果。对象:受试对象共9938人,符合纳入标准且长居深圳市10年以上的健康体检者4123人,男1852人,女2271人,年龄20～79岁,按10岁为1个年龄段,共分6组。方法:将受试者性别、出生日期、身高、体质量输入微机,采用Challerger双能X射线骨密度仪及骨密度分析软件测量非优势(左)股骨近端股骨颈、Ward’s三角区、大转子粗隆骨密度值。主要观察指标:骨密度参考值T值(被测人的骨密度与同性别同年龄人的对照组之差别)及累积丢失率。结果:股骨近端骨峰值出现在20～29岁。成年人骨累积丢失率为:股骨颈>Ward’s三角区>大转子粗隆。在30～39岁组间,男女两性股骨颈和Ward’s三角区的骨密度均呈明显下降趋势;女性50～59岁组间,股骨近端股骨颈、Ward’s三角区、大转子粗隆的骨密度下降速度最快,尤其Ward’s三角区、股骨颈。男性骨密度无明显快速下降年龄段。男女两性随年龄增长骨质疏松症患病率逐渐增高。采用世界卫生组织和中国老年学会骨质疏松委员会制定的骨质疏松症标准,男女两组均在50～79岁及总患病率两独立样本比较,差异有显著性意义(P<0.05),女性尤其明显(P<0.01)。结论:深圳市男女两性在30～39岁间股骨颈、Ward’s三角区骨密度下降明显,女性在50～59岁间骨密度加速下降,应提早加强预防措施。BACKGROUND： Recently, data at home and aboard show the prevalence of osteoporosis has a trend toward young people and greatly significant difference in different areas. OBJECTIVE： To investigate the changing rule of body mineral density （BMD） and prevalence rate of osteoporosis among normal people in Shenzhen area. DESIGN, TIME AND SETTING： Cross-sectional study. The BMD determination results of 4 123 Shenzhen citizens of Han nationality selected from was performed at VIP Health Center of Peking University Shenzhen Hospital between January 2003 and February 2008. PARTICIPANTS： 9 938 persons were enrolled and 4 123 living in Shenzhen more than 10 years and meeting internalize standard were included, including l 852 males and 2 271 females aged 20 79 years. The participants were divided into 6 groups with 10 years as one age group. METHODS： Data such as sex, birth date, body height and body mass were input in computer. By using the Challenger flash DEXA bone densitometer and BMD analyzing software were used to determine BMD rate was measured in left thighbone including proximal femoral neck, Ward＇s and trochanter. MAIN OUTCOME MEASURES： T value of BMD as reference value （difference between the examinees and normal populations） and accumulated loss rate of bone mass. RESULTS： The peak value of BMD in thighbone presented at 20 29 years old. The accumulated loss rate of bone mass was fastest in Ward＇s, followed by the neck and trochanter. At 30 39 years old, the BMD in femoral neck and Ward＇s began to decline significantly. In female between 50 and 59 years old, the decline rate of BMD was the fast, especially in Ward＇s and femoral neck. But in male, such phenomenon was not found. The prevalence of osteoporosis was increased with age. According to the diagnostic standards of osteoporosis of WHO and Osteoporosis Committee of China Gerontological Society, there were significant differences between male and female aged 50-79 years in terms of prevalence of osteoporosis （P 〈 0.05）, espe

关 键 词：骨密度 骨质疏松 患病率 

分 类 号：R681.4[医药卫生—骨科学]